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778  structures 4527  species 18  interactions 48434  sequences 360  architectures

Clan: Dim_A_B_barrel (CL0032)


Dimeric alpha/beta barrel superfamily Add an annotation

This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel. The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases.

This clan contains 25 families and the total number of domains in the clan is 48434. The clan was built by A Bateman.


This clan contains the following 25 member families:

ABM AsnC_trans_reg Chlor_dismutase Cyclase_polyket Dabb Dehydratase_hem DUF1330 DUF1428 DUF3291 DUF4188 DUF4242 DUF4937 Dyp_perox EthD GYD HapK MIase MmlI NapD NIPSNAP rhaM SchA_CurD SOR YCII ydhR

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AsnC_trans_reg (PF01037) 15764 (32.5%) View
ABM (PF03992) 8505 (17.6%) View
YCII (PF03795) 6147 (12.7%) View
Dabb (PF07876) 3107 (6.4%) View
NIPSNAP (PF07978) 2534 (5.2%) View
Dyp_perox (PF04261) 2160 (4.5%) View
EthD (PF07110) 1731 (3.6%) View
DUF1330 (PF07045) 1701 (3.5%) View
rhaM (PF05336) 1521 (3.1%) View
Chlor_dismutase (PF06778) 965 (2.0%) View
DUF1428 (PF07237) 587 (1.2%) View
MIase (PF02426) 516 (1.1%) View
DUF4188 (PF13826) 507 (1.0%) View
Pfam family Num. domains Alignment
DUF4242 (PF14026) 461 (1.0%) View
GYD (PF08734) 406 (0.8%) View
NapD (PF03927) 399 (0.8%) View
DUF3291 (PF11695) 360 (0.7%) View
Dehydratase_hem (PF13816) 262 (0.5%) View
Cyclase_polyket (PF04673) 188 (0.4%) View
ydhR (PF08803) 182 (0.4%) View
DUF4937 (PF16291) 139 (0.3%) View
MmlI (PF09448) 116 (0.2%) View
SchA_CurD (PF04486) 112 (0.2%) View
HapK (PF11639) 46 (0.1%) View
SOR (PF07682) 18 (0.0%) View
Total: 25 Total: 48434 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 18 interactions for this clan. More...

Interacting families
AsnC_trans_reg AsnC_trans_reg
Chlor_dismutase Chlor_dismutase
Dabb Dabb
Dehydratase_hem Dehydratase_hem
DUF1330 DUF1330
DUF1428 DUF1428
Dyp_perox Dyp_perox
EthD EthD
HapK HapK
HTH_24 AsnC_trans_reg
MmlI MmlI
rhaM rhaM
ydhR ydhR


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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