Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
71  structures 4698  species 6  interactions 11883  sequences 77  architectures

Clan: DprA (CL0349)


MoCo carrier protein-like superfamily Add an annotation

Known family members of this superfamily are required for natural chromosomal and plasmid transformation. DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [1]. Superfamily includes lysine_decarboxylases.

This clan contains 5 families and the total number of domains in the clan is 11883. The clan was built by A Bateman.

Literature references

  1. Mortier-Barriere I, Velten M, Dupaigne P, Mirouze N, Pietrement O, McGovern S, Fichant G, Martin B, Noirot P, Le Cam E, Polard P, Claverys JP; , Cell. 2007;130:824-836.: A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA. PUBMED:17803906 EPMC:17803906


This clan contains the following 5 member families:

DNA_processg_A DUF1273 DUF3412 Lysine_decarbox MoCo_carrier

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lysine_decarbox (PF03641) 6282 (52.9%) View
DNA_processg_A (PF02481) 4472 (37.6%) View
DUF1273 (PF06908) 570 (4.8%) View
DUF3412 (PF11892) 418 (3.5%) View
MoCo_carrier (PF12694) 141 (1.2%) View
Total: 5 Total: 11883 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
DUF3412 DUF4478
DUF4478 DUF3412
Lysine_decarbox DUF3412


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...