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1346  structures 22097  species 162  interactions 528032  sequences 14289  architectures

Clan: E-set (CL0159)

Summary

Ig-like fold superfamily (E-set) Add an annotation

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

This clan contains 76 families and the total number of domains in the clan is 528032. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 76 member families:

A2M_N Alpha_adaptinC2 Arch_flagellin Big_1 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 BiPBP_C BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_pro CARDB CBM39 CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N CHU_C Coatamer_beta_C COP-gamma_platf CopC DUF11 DUF2271 DUF3244 DUF4165 DUF4625 DUF5011 DUF916 EpoR_lig-bind Filamin FixG_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 Fn3_assoc He_PIG HYR IFNGR1 IL17R_fnIII_D2 IL6Ra-bind Integrin_alpha2 Interfer-bind Invasin_D3 LEA_2 MG1 Mo-co_dimer Neurexophilin NPCBM_assoc PhoD_N PKD PKD_2 PKD_3 Pur_ac_phosph_N Qn_am_d_aIII REJ RHD_dimer Rib SoxZ SprB SWM_repeat T2SS-T3SS_pil_N TIG Tissue_fac Transglut_C TRAP_beta Y_Y_Y

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Big_3_4 (PF13754) 124741 (23.6%) View
fn3 (PF00041) 77725 (14.7%) View
Cadherin (PF00028) 58220 (11.0%) View
Big_1 (PF02369) 28107 (5.3%) View
Big_2 (PF02368) 21465 (4.1%) View
DUF11 (PF01345) 15955 (3.0%) View
Fn3-like (PF14310) 15439 (2.9%) View
TIG (PF01833) 12418 (2.4%) View
Filamin (PF00630) 11782 (2.2%) View
A2M_N (PF01835) 9003 (1.7%) View
PKD (PF00801) 8686 (1.6%) View
Big_3_2 (PF12245) 7185 (1.4%) View
CopC (PF04234) 6235 (1.2%) View
FlgD_ig (PF13860) 6227 (1.2%) View
Y_Y_Y (PF07495) 6189 (1.2%) View
Cadherin_3 (PF16184) 5943 (1.1%) View
Big_3 (PF07523) 5932 (1.1%) View
DUF5011 (PF16403) 5087 (1.0%) View
Big_5 (PF13205) 4958 (0.9%) View
He_PIG (PF05345) 4913 (0.9%) View
BiPBP_C (PF06832) 4714 (0.9%) View
MG1 (PF11974) 4706 (0.9%) View
DUF916 (PF06030) 4650 (0.9%) View
Pur_ac_phosph_N (PF16656) 4541 (0.9%) View
Mo-co_dimer (PF03404) 4357 (0.8%) View
Big_4 (PF07532) 3834 (0.7%) View
LEA_2 (PF03168) 3753 (0.7%) View
Rib (PF08428) 3619 (0.7%) View
FixG_C (PF11614) 3238 (0.6%) View
Cadherin_2 (PF08266) 2908 (0.6%) View
fn3_5 (PF06280) 2896 (0.5%) View
PhoD_N (PF16655) 2887 (0.5%) View
CHB_HEX_C (PF03174) 2822 (0.5%) View
NPCBM_assoc (PF10633) 2753 (0.5%) View
T2SS-T3SS_pil_N (PF13629) 2631 (0.5%) View
CARDB (PF07705) 2449 (0.5%) View
Alpha_adaptinC2 (PF02883) 2419 (0.5%) View
HYR (PF02494) 2317 (0.4%) View
CHU_C (PF13585) 2188 (0.4%) View
continued
Pfam family Num. domains Alignment
Integrin_alpha2 (PF08441) 1963 (0.4%) View
SprB (PF13573) 1903 (0.4%) View
Big_3_5 (PF16640) 1648 (0.3%) View
Invasin_D3 (PF09134) 1566 (0.3%) View
Cadherin-like (PF12733) 1468 (0.3%) View
Transglut_C (PF00927) 1361 (0.3%) View
RHD_dimer (PF16179) 1252 (0.2%) View
REJ (PF02010) 1167 (0.2%) View
Tissue_fac (PF01108) 1040 (0.2%) View
DUF2271 (PF10029) 1023 (0.2%) View
Interfer-bind (PF09294) 945 (0.2%) View
Fn3_assoc (PF13287) 896 (0.2%) View
Arch_flagellin (PF01917) 830 (0.2%) View
COP-gamma_platf (PF08752) 825 (0.2%) View
SoxZ (PF08770) 766 (0.1%) View
ChitinaseA_N (PF08329) 725 (0.1%) View
Neurexophilin (PF06312) 719 (0.1%) View
IL6Ra-bind (PF09240) 694 (0.1%) View
Coatamer_beta_C (PF07718) 691 (0.1%) View
EpoR_lig-bind (PF09067) 665 (0.1%) View
SWM_repeat (PF13753) 620 (0.1%) View
DUF3244 (PF11589) 589 (0.1%) View
Cadherin_pro (PF08758) 540 (0.1%) View
CHB_HEX_C_1 (PF13290) 530 (0.1%) View
Big_3_3 (PF13750) 468 (0.1%) View
PKD_3 (PF16820) 415 (0.1%) View
CBM39 (PF15886) 400 (0.1%) View
TRAP_beta (PF05753) 377 (0.1%) View
DUF4165 (PF13752) 310 (0.1%) View
BsuPI (PF12690) 302 (0.1%) View
DUF4625 (PF15418) 292 (0.1%) View
fn3_2 (PF16893) 272 (0.1%) View
PKD_2 (PF16407) 263 (0.0%) View
fn3_4 (PF16794) 216 (0.0%) View
IFNGR1 (PF07140) 152 (0.0%) View
IL17R_fnIII_D2 (PF16578) 134 (0.0%) View
Qn_am_d_aIII (PF09099) 113 (0.0%) View
Total: 76 Total: 528032 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 162 interactions for this clan. More...

Interacting families
A B
A2M A2M_N
A2M_comp A2M_N
A2M_N A2M
A2M_comp
A2M_N
A2M_N_2
A2M_recep
Stap_Strp_tox_C
Sushi
Thiol-ester_cl
Trypsin
Alpha-amylase TIG
Alpha-amylase_C TIG
Alpha_adaptinC2 Alpha_adaptin_C
Alpha_adaptinC2
B2-adapt-app_C
Ank_2 TIG
Ank_4 TIG
Big_1 Big_1
Big_2
Invasin_D3
Big_2 Big_2
Intimin_C
Big_3 LRR_5
Cadherin Cadherin
Lectin_C
CARDB CARDB
CH fn3
CHB_HEX CHB_HEX_C
ChitinaseA_N ChitinaseA_N
Glyco_hydro_18
CopC CopC
DUF3244 DUF3244
EGF Interfer-bind
Tissue_fac
EPO_TPO EpoR_lig-bind
fn3
EpoR_lig-bind EPO_TPO
EpoR_lig-bind
fn3
FG-GAP Integrin_alpha2
Filamin Filamin
Integrin_b_cyt
FlgD_ig FlgD_ig
FLgD_tudor
FLgD_tudor FlgD_ig
fn3 EPO_TPO
EpoR_lig-bind
fn3
Glyco_hydro_28
HH_signal
Hormone_1
I-set
IL2
IL6
Lectin_C
LIF_OSM
Pectate_lyase_3
Pkinase
RGM_C
RGM_N
V-set
Fn3-like Glyco_hydro_3
Glyco_hydro_3_C
Forkhead TIG
Gla Interfer-bind
Glyco_hydro_20 CHB_HEX_C
Glyco_hydro_28 fn3
Glyco_hydro_3 Fn3-like
Glyco_hydro_3_C Fn3-like
HH_signal fn3
Hormone_1 EpoR_lig-bind
fn3
Hormone_recep fn3
I-set fn3
IFN-gamma IFNGR1
Tissue_fac
IFNGR1 IFN-gamma
IFNGR1
ig fn3
Ig_2 fn3
IL10 Interfer-bind
Tissue_fac
IL15 fn3
IL6Ra-bind
IL2 fn3
IL6Ra-bind
IL22 Tissue_fac
IL28A Tissue_fac
IL4 fn3
IL6Ra-bind
IL5 IL6Ra-bind
IL6 IL6Ra-bind
IL6Ra-bind fn3
IL2
IL5
IL6
IL6Ra-bind
LIF_OSM
IL7 fn3
Integrin_alpha2 Integrin_alpha2
Integrin_B_tail
Integrin_beta
Interfer-bind EGF
IL22
Interfer-bind
Interferon
Tissue_fac
Interferon Interfer-bind
Tissue_fac
Intimin_C Big_2
Lactonase PKD
LAG1-DNAbind TIG
Lep_receptor_Ig IL6Ra-bind
Lipocalin fn3
LRR_4 Cadherin
TIG
MatE fn3
Mo-co_dimer Cytochrome_CBB3
Mo-co_dimer
Oxidored_molyb
NPCBM_assoc F5_F8_type_C
NPCBM_assoc
Oxidored_molyb Mo-co_dimer
Peptidase_S8 CHU_C
fn3_5
PKD Lactonase
PKD
PSI TIG
Qn_am_d_aII Qn_am_d_aIII
Qn_am_d_aIII Qn_am_d_aIV
Ras TIG
Reg_prop Y_Y_Y
RHD_DNA_bind TIG
Sema TIG
SoxY SoxZ
SoxZ SoxY
SoxZ
TIG Ank_2
Ank_4
bZIP_1
CBM_20
Forkhead
MamL-1
RHD_DNA_bind
Sema
TIG
Tissue_fac EGF
IFNGR1
IL10
IL22
Interfer-bind
Interferon
Trypsin
Transglut_C Transglut_C
Transglut_core
Transglut_N
Transglut_core Transglut_C
Transglut_N Transglut_C
Trypsin Tissue_fac
Y_Y_Y Reg_prop
Y_Y_Y

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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