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2075  structures 2008  species 172  interactions 182089  sequences 9336  architectures

Clan: E-set (CL0159)

Summary

Ig-like fold superfamily (E-set) Add an annotation

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

This clan contains 81 families and the total number of domains in the clan is 182089. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 81 member families:

A2M_N Alpha_adaptinC2 Arch_flagellin Big_1 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_5 Big_4 Big_5 BiPBP_C BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_pro CARDB CBM39 CelD_N CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N CHU_C Coatamer_beta_C COP-gamma_platf CopC DUF11 DUF2271 DUF3244 DUF4165 DUF4625 DUF5011 DUF916 EpoR_lig-bind Filamin FixG_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 Fn3_assoc Glyco_hydro_61 He_PIG HYR IFNGR1 IL12p40_C IL17R_fnIII_D2 IL4Ra_N IL6Ra-bind Integrin_alpha2 Interfer-bind Invasin_D3 LEA_2 Lep_receptor_Ig LPMO_10 MG1 Mo-co_dimer Neurexophilin NPCBM_assoc PhoD_N PKD PKD_2 PKD_3 Pur_ac_phosph_N Qn_am_d_aIII REJ RHD_dimer Rib SoxZ SprB SWM_repeat T2SS-T3SS_pil_N TIG Tissue_fac Transglut_C TRAP_beta Y_Y_Y

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
fn3 (PF00041) 57455 (31.6%) View
Cadherin (PF00028) 47291 (26.0%) View
Filamin (PF00630) 8736 (4.8%) View
TIG (PF01833) 8186 (4.5%) View
Cadherin_3 (PF16184) 4976 (2.7%) View
PKD (PF00801) 3984 (2.2%) View
Fn3-like (PF14310) 3730 (2.0%) View
Big_2 (PF02368) 3365 (1.8%) View
Cadherin_2 (PF08266) 2364 (1.3%) View
LEA_2 (PF03168) 1976 (1.1%) View
HYR (PF02494) 1857 (1.0%) View
DUF11 (PF01345) 1714 (0.9%) View
Alpha_adaptinC2 (PF02883) 1705 (0.9%) View
Integrin_alpha2 (PF08441) 1572 (0.9%) View
Pur_ac_phosph_N (PF16656) 1542 (0.8%) View
A2M_N (PF01835) 1493 (0.8%) View
Glyco_hydro_61 (PF03443) 1446 (0.8%) View
Y_Y_Y (PF07495) 1287 (0.7%) View
He_PIG (PF05345) 1213 (0.7%) View
Transglut_C (PF00927) 1076 (0.6%) View
Mo-co_dimer (PF03404) 1054 (0.6%) View
Big_5 (PF13205) 1046 (0.6%) View
SprB (PF13573) 972 (0.5%) View
CARDB (PF07705) 964 (0.5%) View
Big_3_2 (PF12245) 961 (0.5%) View
CHU_C (PF13585) 934 (0.5%) View
Big_3_5 (PF16640) 897 (0.5%) View
LPMO_10 (PF03067) 851 (0.5%) View
RHD_dimer (PF16179) 830 (0.5%) View
Tissue_fac (PF01108) 745 (0.4%) View
CHB_HEX_C_1 (PF13290) 735 (0.4%) View
Cadherin-like (PF12733) 713 (0.4%) View
FlgD_ig (PF13860) 686 (0.4%) View
Interfer-bind (PF09294) 672 (0.4%) View
Neurexophilin (PF06312) 669 (0.4%) View
PhoD_N (PF16655) 645 (0.4%) View
REJ (PF02010) 642 (0.4%) View
DUF5011 (PF16403) 613 (0.3%) View
fn3_5 (PF06280) 549 (0.3%) View
COP-gamma_platf (PF08752) 547 (0.3%) View
CopC (PF04234) 537 (0.3%) View
continued
Pfam family Num. domains Alignment
Coatamer_beta_C (PF07718) 463 (0.3%) View
IL6Ra-bind (PF09240) 442 (0.2%) View
FixG_C (PF11614) 437 (0.2%) View
Cadherin_pro (PF08758) 435 (0.2%) View
EpoR_lig-bind (PF09067) 410 (0.2%) View
T2SS-T3SS_pil_N (PF13629) 406 (0.2%) View
Fn3_assoc (PF13287) 377 (0.2%) View
MG1 (PF11974) 348 (0.2%) View
Big_3 (PF07523) 348 (0.2%) View
BiPBP_C (PF06832) 338 (0.2%) View
Big_4 (PF07532) 335 (0.2%) View
Big_1 (PF02369) 329 (0.2%) View
NPCBM_assoc (PF10633) 319 (0.2%) View
CelD_N (PF02927) 307 (0.2%) View
Arch_flagellin (PF01917) 305 (0.2%) View
Lep_receptor_Ig (PF06328) 302 (0.2%) View
TRAP_beta (PF05753) 250 (0.1%) View
SoxZ (PF08770) 241 (0.1%) View
DUF916 (PF06030) 239 (0.1%) View
SWM_repeat (PF13753) 230 (0.1%) View
Rib (PF08428) 195 (0.1%) View
fn3_2 (PF16893) 188 (0.1%) View
fn3_4 (PF16794) 176 (0.1%) View
CBM39 (PF15886) 158 (0.1%) View
DUF2271 (PF10029) 153 (0.1%) View
Invasin_D3 (PF09134) 139 (0.1%) View
Big_3_3 (PF13750) 120 (0.1%) View
PKD_2 (PF16407) 112 (0.1%) View
IL17R_fnIII_D2 (PF16578) 109 (0.1%) View
CHB_HEX_C (PF03174) 103 (0.1%) View
IL12p40_C (PF10420) 94 (0.1%) View
DUF3244 (PF11589) 72 (0.0%) View
BsuPI (PF12690) 70 (0.0%) View
IL4Ra_N (PF09238) 68 (0.0%) View
PKD_3 (PF16820) 64 (0.0%) View
DUF4625 (PF15418) 61 (0.0%) View
IFNGR1 (PF07140) 44 (0.0%) View
ChitinaseA_N (PF08329) 41 (0.0%) View
Qn_am_d_aIII (PF09099) 19 (0.0%) View
DUF4165 (PF13752) 12 (0.0%) View
Total: 81 Total: 182089 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 172 interactions for this clan. More...

Interacting families
A B
A2M A2M_N
A2M_comp A2M_N
A2M_N A2M
A2M_comp
A2M_N
A2M_N_2
A2M_recep
Stap_Strp_tox_C
Sushi
Thiol-ester_cl
Trypsin
Alpha-amylase TIG
Alpha-amylase_C TIG
Alpha_adaptinC2 Alpha_adaptin_C
Alpha_adaptinC2
B2-adapt-app_C
Ank_2 TIG
Ank_4 TIG
Big_1 Big_1
Big_2
Invasin_D3
Big_2 Big_2
Intimin_C
Big_3 LRR_5
Cadherin Cadherin
Lectin_C
CARDB CARDB
CBM_4_9 CelD_N
CelD_N Glyco_hydro_9
CH fn3
CHB_HEX CHB_HEX_C
ChitinaseA_N ChitinaseA_N
Glyco_hydro_18
CopC CopC
DUF3244 DUF3244
EGF Interfer-bind
Tissue_fac
EPO_TPO EpoR_lig-bind
fn3
EpoR_lig-bind EPO_TPO
EpoR_lig-bind
fn3
FG-GAP Integrin_alpha2
Filamin Filamin
Integrin_b_cyt
FlgD_ig FlgD_ig
FLgD_tudor
FLgD_tudor FlgD_ig
fn3 EPO_TPO
EpoR_lig-bind
fn3
Glyco_hydro_28
HH_signal
Hormone_1
I-set
IL2
IL6
Lectin_C
LIF_OSM
Pectate_lyase_3
Pkinase
RGM_C
RGM_N
V-set
Fn3-like Glyco_hydro_3
Glyco_hydro_3_C
Forkhead TIG
Gla Interfer-bind
Glyco_hydro_20 CHB_HEX_C
Glyco_hydro_28 fn3
Glyco_hydro_3 Fn3-like
Glyco_hydro_3_C Fn3-like
Glyco_hydro_61 Glyco_hydro_61
Glyco_hydro_9 CelD_N
HH_signal fn3
Hormone_1 EpoR_lig-bind
fn3
Hormone_recep fn3
I-set fn3
IFN-gamma IFNGR1
Tissue_fac
IFNGR1 IFN-gamma
IFNGR1
ig fn3
Ig_2 fn3
IL10 Interfer-bind
Tissue_fac
IL12p40_C IL12
IL6
IL13 IL4Ra_N
IL15 fn3
IL6Ra-bind
IL2 fn3
IL6Ra-bind
IL22 Tissue_fac
IL28A Tissue_fac
IL4 fn3
IL4Ra_N
IL6Ra-bind
IL5 IL6Ra-bind
IL6 IL12p40_C
IL6Ra-bind
IL6Ra-bind fn3
IL2
IL5
IL6
IL6Ra-bind
LIF_OSM
IL7 fn3
Integrin_alpha2 Integrin_alpha2
Integrin_B_tail
Integrin_beta
Interfer-bind EGF
IL22
Interfer-bind
Interferon
Tissue_fac
Interferon Interfer-bind
Tissue_fac
Intimin_C Big_2
Lactonase PKD
LAG1-DNAbind TIG
Lep_receptor_Ig IL6Ra-bind
Lipocalin fn3
LPMO_10 LPMO_10
LRR_4 Cadherin
TIG
MatE fn3
Mo-co_dimer Cytochrome_CBB3
Mo-co_dimer
Oxidored_molyb
NPCBM_assoc F5_F8_type_C
NPCBM_assoc
Oxidored_molyb Mo-co_dimer
Peptidase_S8 CHU_C
fn3_5
PKD Lactonase
PKD
PSI TIG
Qn_am_d_aII Qn_am_d_aIII
Qn_am_d_aIII Qn_am_d_aIV
Ras TIG
Reg_prop Y_Y_Y
RHD_DNA_bind TIG
Sema TIG
SoxY SoxZ
SoxZ SoxY
SoxZ
TIG Ank_2
Ank_4
bZIP_1
CBM_20
Forkhead
MamL-1
RHD_DNA_bind
Sema
TIG
Tissue_fac EGF
IFNGR1
IL10
IL22
Interfer-bind
Interferon
Trypsin
Transglut_C Transglut_C
Transglut_core
Transglut_N
Transglut_core Transglut_C
Transglut_N Transglut_C
Trypsin Tissue_fac
Y_Y_Y Reg_prop
Y_Y_Y

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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