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26  structures 8312  species 2  interactions 10072  sequences 60  architectures

Clan: Endonuclease (CL0189)


Endonuclease V-like superfamily Add an annotation

This clan contains DNA repair proteins. In E. coli endonuclease V initiates DNA repair of deaminated DNA bases and has similarity to motifs required for the catalytic activity of the UvrC endonuclease [1].

This clan contains 2 families and the total number of domains in the clan is 10072. The clan was built by A Wuster.

Literature references

  1. Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjoras M, Seeberg E, Rognes T, Klungland A; , Nucleic Acids Res 2003;31:3893-3900.: Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V. PUBMED:12853604 EPMC:12853604


This clan contains the following 2 member families:

Endonuclease_5 UvrC_HhH_N

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UvrC_HhH_N (PF08459) 7912 (78.6%) View
Endonuclease_5 (PF04493) 2160 (21.4%) View
Total: 2 Total: 10072 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
Endonuclease_5 Endonuclease_5
UvrC_HhH_N UvrC_HhH_N


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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