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580  structures 5322  species 28  interactions 39865  sequences 452  architectures

Clan: FKBP (CL0487)

Summary

FKBP-like superfamily Add an annotation

This superfamily includes the FKBP domain which catalyses the peptidyl-prolyl cis-trans isomerisation reaction. The superfamily also includes the C-terminal domain of GreA and the c-terminal dmoain of 3-mercaptopyruvate sulfurtransferase.

This clan contains 9 families and the total number of domains in the clan is 39865. The clan was built by A Bateman.

Members

This clan contains the following 9 member families:

DUF1930 DUF4827 FKBP_C GCD14_N GreA_GreB OSR1_C Rotamase Rotamase_2 Rotamase_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FKBP_C (PF00254) 19610 (49.2%) View
GreA_GreB (PF01272) 6843 (17.2%) View
Rotamase_3 (PF13616) 4827 (12.1%) View
Rotamase (PF00639) 4497 (11.3%) View
Rotamase_2 (PF13145) 2208 (5.5%) View
OSR1_C (PF12202) 1102 (2.8%) View
GCD14_N (PF14801) 640 (1.6%) View
DUF4827 (PF16109) 124 (0.3%) View
DUF1930 (PF09122) 14 (0.0%) View
Total: 9 Total: 39865 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 28 interactions for this clan. More...

Interacting families
A B
EF-hand_7 FKBP_C
FKBP_C EF-hand_7
FKBP_C
FRB_dom
Pkinase
TGF_beta_GS
TPR_1
TPR_11
Trigger_C
FKBP_N FKBP_C
GCD14_N GCD14
GreA_GreB GreA_GreB
GreA_GreB_N
Rnk_N
GreA_GreB_N GreA_GreB
Metallophos FKBP_C
Pkinase FKBP_C
Rad60-SLD FKBP_C
Rhodanese DUF1930
RNA_pol_Rpb1_4 GreA_GreB
RNA_pol_Rpb2_2 GreA_GreB
Rnk_N GreA_GreB
Rotamase Rotamase
SurA_N
SurA_N Rotamase
TGF_beta_GS FKBP_C
TPR_1 FKBP_C
WW Rotamase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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