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286  structures 1936  species 12  interactions 11876  sequences 148  architectures

Clan: FMN-binding (CL0336)


FMN-binding split barrel superfamily Add an annotation

This includes those related to the ferredoxin reductase-like FAD-binding domain and those that are Pyridoxine 5'-phosphate oxidase (PNP)-like.

This clan contains 9 families and the total number of domains in the clan is 11876. The clan was built by P Coggill.


This clan contains the following 9 member families:

DUF385 DUF447 Flavin_Reduct FMN_bind_2 Pyrid_ox_like Pyrid_oxidase_2 Pyridox_ox_2 Pyridox_oxase_2 Pyridox_oxidase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pyridox_oxidase (PF01243) 4261 (35.9%) View
Flavin_Reduct (PF01613) 3772 (31.8%) View
Pyridox_ox_2 (PF12900) 1127 (9.5%) View
DUF385 (PF04075) 689 (5.8%) View
Pyrid_oxidase_2 (PF13883) 622 (5.2%) View
FMN_bind_2 (PF04299) 492 (4.1%) View
Pyrid_ox_like (PF16242) 442 (3.7%) View
Pyridox_oxase_2 (PF12766) 328 (2.8%) View
DUF447 (PF04289) 143 (1.2%) View
Total: 9 Total: 11876 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
DUF2470 Pyridox_oxidase
DUF385 DUF385
DUF447 DUF447
Flavin_Reduct Flavin_Reduct
FMN_bind_2 FMN_bind_2
PNPOx_C Pyridox_oxidase
Pyrid_oxidase_2 Pyrid_oxidase_2
Pyridox_ox_2 Pyridox_ox_2
Pyridox_oxase_2 Pyridox_oxase_2
Pyridox_oxidase DUF2470


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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