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370  structures 8155  species 1  interaction 33794  sequences 237  architectures

Clan: FMN-dep-NRtase (CL0529)


FMN-dependent nitroreductase-like Add an annotation

This superfamily is involved in the reduction of nitrogen containing compounds. Members of this family utilise FMN as a cofactor and are often found to be homodimers. Possible characteristics include Oxygen-insensitive NAD(P)H nitroreductase (FMN-dependent nitroreductase) (Dihydropteridine reductase) and NADH dehydrogenase. A number of the proteins are described as oxidoreductases. They are primarily found in bacterial lineages though a number of eukaryotic homologues have been identified: Caenorhabditis elegans, Drosophila melanogaster, mouse and human. These protein are not found in photosynthetic eukaryotes; sequences containing this entry in photosynthetic organisms are possible false positives.

This clan contains 5 families and the total number of domains in the clan is 33794. The clan was built by P Coggill.


This clan contains the following 5 member families:

Dehalogenase MMACHC MMADHC Nitroreductase TM1586_NiRdase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Nitroreductase (PF00881) 31719 (93.9%) View
TM1586_NiRdase (PF14512) 810 (2.4%) View
MMADHC (PF10229) 528 (1.6%) View
Dehalogenase (PF13486) 431 (1.3%) View
MMACHC (PF16690) 306 (0.9%) View
Total: 5 Total: 33794 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
Nitroreductase Nitroreductase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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