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413  structures 19771  species 51  interactions 142484  sequences 527  architectures

Clan: Fer2 (CL0486)


2Fe-2S iron-sulfur cluster binding domain Add an annotation

The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domani is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.

This clan contains 5 families and the total number of domains in the clan is 142484. The clan was built by A Bateman.

Literature references

  1. Armengaud J, Sainz G, Jouanneau Y, Sieker LC;, Acta Crystallogr D Biol Crystallogr. 2001;57:301-303.: Crystallization and preliminary X-ray diffraction analysis of a [2Fe-2S] ferredoxin (FdVI) from Rhodobacter capsulatus. PUBMED:11173487 EPMC:11173487


This clan contains the following 5 member families:

DHODB_Fe-S_bind Fer2 Fer2_2 Fer2_3 Fer2_4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fer2 (PF00111) 69259 (48.6%) View
Fer2_3 (PF13085) 24370 (17.1%) View
Fer2_4 (PF13510) 21802 (15.3%) View
Fer2_2 (PF01799) 19267 (13.5%) View
DHODB_Fe-S_bind (PF10418) 7786 (5.5%) View
Total: 5 Total: 142484 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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