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767  structures 8694  species 12  interactions 58542  sequences 447  architectures

Clan: Flavoprotein (CL0042)


Flavoprotein Add an annotation

Members of this clan are FMN or FAD-binding redox proteins. Flavoproteins act in various electron-transport systems as functional analogues of ferredoxin. They are characterised by an open twisted alpha/beta structure consisting of five parallel beta-sheets connected by alpha-helices which surround the sheet.

This clan contains 7 families and the total number of domains in the clan is 58542. The clan was built by RD Finn.


This clan contains the following 7 member families:

Flavodoxin_1 Flavodoxin_2 Flavodoxin_3 Flavodoxin_4 Flavodoxin_5 Flavodoxin_NdrI FMN_red

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FMN_red (PF03358) 26117 (44.6%) View
Flavodoxin_1 (PF00258) 14586 (24.9%) View
Flavodoxin_2 (PF02525) 10846 (18.5%) View
Flavodoxin_5 (PF12724) 2913 (5.0%) View
Flavodoxin_4 (PF12682) 1911 (3.3%) View
Flavodoxin_NdrI (PF07972) 1608 (2.7%) View
Flavodoxin_3 (PF12641) 561 (1.0%) View
Total: 7 Total: 58542 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
FAD_binding_1 Flavodoxin_1
Flavodoxin_1 EF-hand_7
Flavodoxin_2 Flavodoxin_2
Flavodoxin_4 Flavodoxin_4
FMN_red FMN_red
Lactamase_B Flavodoxin_1
p450 Flavodoxin_1
Ribonuc_red_sm Flavodoxin_NdrI


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...