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61  structures 248  species 9  interactions 9797  sequences 775  architectures

Clan: FnI-like (CL0451)


von Willebrand Factor like superfamily Add an annotation

This superfamily is characterised by being disulfide-rich, all-beta with an extra C-terminal domain in the fibronectin-like, Fn1, members.

This clan contains 5 families and the total number of domains in the clan is 9797. The clan was built by P Coggill.


This clan contains the following 5 member families:

fn1 Pacifastin_I PSP94 TILa VWC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
VWC (PF00093) 5867 (59.9%) View
fn1 (PF00039) 2045 (20.9%) View
TILa (PF12714) 1298 (13.2%) View
Pacifastin_I (PF05375) 370 (3.8%) View
PSP94 (PF05825) 217 (2.2%) View
Total: 5 Total: 9797 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 9 interactions for this clan. More...

Interacting families
fn1 Collagen
fn2 fn1
Pacifastin_I Trypsin
Trypsin Pacifastin_I


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...