Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 608  species 0  interactions 3081  sequences 47  architectures

Clan: GCP (CL0540)


Gamma-tubulin complex superfamily Add an annotation

This superfamily carries families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome.

This clan contains 2 families and the total number of domains in the clan is 3081. The clan was built by P Coggill.

Literature references

  1. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T;, Mol Biol Cell. 2001;12:3340-3352.: GCP5 and GCP6: two new members of the human gamma-tubulin complex. PUBMED:11694571 EPMC:11694571


This clan contains the following 2 member families:

GCP5-Mod21 Spc97_Spc98

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Spc97_Spc98 (PF04130) 3074 (99.8%) View
GCP5-Mod21 (PF14609) 7 (0.2%) View
Total: 2 Total: 3081 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...