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1174  structures 7203  species 39  interactions 76165  sequences 1736  architectures

Clan: GHD (CL0369)


Glycosyl hydrolase domain superfamily Add an annotation

This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.

This clan contains 39 families and the total number of domains in the clan is 76165. The clan was built by A Bateman.


This clan contains the following 39 member families:

Alpha-amyl_C Alpha-amyl_C2 Alpha-amylase_C Alpha-L-AF_C AMPK1_CBM Bac_A_amyl_C BetaGal_dom2 CBM_20 CBM_48 Collagen_bind_2 Cyc-maltodext_C DUF1921 DUF1923 DUF1939 DUF1945 DUF1953 DUF1964 DUF1966 DUF3372 DUF3459 Fucosidase_C GH97_C GHD GlgX_C Glyc_hyd_38C_2 Glyco_hyd_101C Glyco_hydro38C2 Glyco_hydro_30C Glyco_hydro_36C Glyco_hydro_42C Glyco_hydro_5_C HepII_C hGDE_central Lact_bio_phlase LBP_C Malt_amylase_C Melibiase_2_C Melibiase_C SpuA_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CBM_48 (PF02922) 14945 (19.6%) View
Alpha-amylase_C (PF02806) 8576 (11.3%) View
DUF3459 (PF11941) 5019 (6.6%) View
Malt_amylase_C (PF16657) 4988 (6.5%) View
AMPK1_CBM (PF16561) 4544 (6.0%) View
Alpha-L-AF_C (PF06964) 4430 (5.8%) View
Melibiase_C (PF17801) 3909 (5.1%) View
CBM_20 (PF00686) 3908 (5.1%) View
Glyco_hydro38C2 (PF17677) 3523 (4.6%) View
Glyco_hydro_30C (PF17189) 2855 (3.7%) View
Glyco_hydro_36C (PF16874) 2551 (3.3%) View
GH97_C (PF14509) 2319 (3.0%) View
GHD (PF17834) 1961 (2.6%) View
Glyco_hydro_42C (PF08533) 1715 (2.3%) View
Fucosidase_C (PF16757) 1410 (1.9%) View
Glyco_hydro_5_C (PF18564) 1256 (1.6%) View
BetaGal_dom2 (PF10435) 1158 (1.5%) View
hGDE_central (PF14702) 1004 (1.3%) View
DUF3372 (PF11852) 932 (1.2%) View
DUF1966 (PF09260) 803 (1.1%) View
Pfam family Num. domains Alignment
Cyc-maltodext_C (PF10438) 717 (0.9%) View
Alpha-amyl_C2 (PF07821) 709 (0.9%) View
Collagen_bind_2 (PF12904) 610 (0.8%) View
DUF1939 (PF09154) 503 (0.7%) View
Melibiase_2_C (PF17450) 452 (0.6%) View
Lact_bio_phlase (PF09508) 303 (0.4%) View
LBP_C (PF17386) 289 (0.4%) View
Glyco_hyd_101C (PF17451) 227 (0.3%) View
GlgX_C (PF18390) 172 (0.2%) View
SpuA_C (PF18033) 122 (0.2%) View
Bac_A_amyl_C (PF18612) 94 (0.1%) View
HepII_C (PF18675) 58 (0.1%) View
Glyc_hyd_38C_2 (PF18230) 40 (0.1%) View
DUF1964 (PF09244) 35 (0.0%) View
DUF1921 (PF09081) 18 (0.0%) View
Alpha-amyl_C (PF09071) 5 (0.0%) View
DUF1945 (PF09178) 2 (0.0%) View
DUF1923 (PF09083) 2 (0.0%) View
DUF1953 (PF09196) 1 (0.0%) View
Total: 39 Total: 76165 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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