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745  structures 1692  species 30  interactions 13289  sequences 449  architectures

Clan: GHD (CL0369)

Summary

Glycosyl hydrolase domain superfamily Add an annotation

This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.

This clan contains 20 families and the total number of domains in the clan is 13289. The clan was built by A Bateman.

Members

This clan contains the following 20 member families:

Alpha-amyl_C Alpha-amyl_C2 Alpha-amylase_C Alpha-L-AF_C AMPK1_CBM CBM_20 CBM_48 Cyc-maltodext_C DUF1921 DUF1923 DUF1939 DUF1945 DUF1953 DUF1964 DUF1966 DUF3372 DUF3459 Glyco_hydro_30C Glyco_hydro_42C Malt_amylase_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CBM_48 (PF02922) 3464 (26.1%) View
Alpha-amylase_C (PF02806) 2235 (16.8%) View
AMPK1_CBM (PF16561) 1428 (10.7%) View
CBM_20 (PF00686) 1291 (9.7%) View
Alpha-L-AF_C (PF06964) 1055 (7.9%) View
Malt_amylase_C (PF16657) 1049 (7.9%) View
DUF3459 (PF11941) 851 (6.4%) View
Glyco_hydro_30C (PF17189) 704 (5.3%) View
Glyco_hydro_42C (PF08533) 307 (2.3%) View
Alpha-amyl_C2 (PF07821) 264 (2.0%) View
DUF1966 (PF09260) 222 (1.7%) View
DUF3372 (PF11852) 174 (1.3%) View
Cyc-maltodext_C (PF10438) 129 (1.0%) View
DUF1939 (PF09154) 98 (0.7%) View
DUF1964 (PF09244) 9 (0.1%) View
DUF1921 (PF09081) 3 (0.0%) View
Alpha-amyl_C (PF09071) 3 (0.0%) View
DUF1953 (PF09196) 1 (0.0%) View
DUF1945 (PF09178) 1 (0.0%) View
DUF1923 (PF09083) 1 (0.0%) View
Total: 20 Total: 13289 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 30 interactions for this clan. More...

Interacting families
A B
Alpha-amylase Alpha-amyl_C
Alpha-amyl_C2
Alpha-amylase_C
CBM_20
CBM_48
Cyc-maltodext_C
DUF1921
DUF1939
DUF1945
DUF1953
DUF1964
DUF1966
DUF3372
DUF3459
Alpha-amylase_C Alpha-amylase
Alpha-amylase_C
CBM_48
TIG
Alpha-L-AF_C Alpha-L-AF_C
CBM_20 CBM_20
Glyco_hydro_14
CBM_48 Alpha-amylase
Cyc-maltodext_C Alpha-amylase
DUF1966 Alpha-amylase
Glyco_hydro_14 CBM_20
Glyco_hydro_15 CBM_20
Glyco_hydro_42 Glyco_hydro_42C
Glyco_hydro_42M Glyco_hydro_42C
Glyco_hydro_44 Alpha-L-AF_C
TIG CBM_20

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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