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4  structures 1041  species 1  interaction 1923  sequences 50  architectures

Clan: GHKL (CL0565)

Summary

ATPase domain of HSP90, DNA topoisomerase II and histidine kinase Add an annotation

The GHKL (gyrase, Hsp90, histidine kinase, MutL) superfamily is characterised by an eight-stranded mixed beta-sheet in two layers - alpha/beta. This is the unconventional Bergerat ATP-binding fold and is thus the most singular unifying feature of this superfamily.

This clan contains 1 families and the total number of domains in the clan is 1923. The clan was built by P Coggill.

Literature references

  1. Dutta R, Inouye M;, Trends Biochem Sci. 2000;25:24-28.: GHKL, an emergent ATPase/kinase superfamily. PUBMED:10637609 EPMC:10637609

Members

This clan contains the following 1 member families:

HATPase_c_4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HATPase_c_4 (PF13749) 1923 (100.0%) View
Total: 1 Total: 1923 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
AlbA_2 HATPase_c_4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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