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117  structures 3437  species 5  interactions 6472  sequences 27  architectures

Clan: GME (CL0197)

Summary

GME superfamily Add an annotation

This superfamily contains a number of related enzymes such as AstB, peptidyl-arginine deiminase, arginine deiminase and amidinotransferase [1,2].

This clan contains 4 families and the total number of domains in the clan is 6472. The clan was built by A Bateman and H Shirai.

Literature references

  1. Shirai H, Blundell TL, Mizuguchi K; , Trends Biochem Sci 2001;26:465-468.: A novel superfamily of enzymes that catalyze the modification of guanidino groups. PUBMED:11504612 EPMC:11504612
  2. Shirai H, Mizuguchi K; , FEBS Lett 2003;555:505-510.: Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism. PUBMED:14675764 EPMC:14675764

Members

This clan contains the following 4 member families:

Amidinotransf AstB PAD PAD_porph

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Amidinotransf (PF02274) 3546 (54.8%) View
PAD_porph (PF04371) 1778 (27.5%) View
AstB (PF04996) 825 (12.7%) View
PAD (PF03068) 323 (5.0%) View
Total: 4 Total: 6472 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
PAD PAD
PAD_N
PAD_M
Amidinotransf Amidinotransf
PAD_porph PAD_porph

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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