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694  structures 7559  species 19  interactions 174162  sequences 2831  architectures

Clan: GPCR_A (CL0192)


Family A G protein-coupled receptor-like superfamily Add an annotation

This clan contains various seven-transmembrane receptors and related proteins. A major member is Pfam:PF00001, members of which have been considered to be typical members of the rhodopsin superfamily. Many members of this clan are Caenorhabditis proteins, suggesting great expansion of the relevant families in these nematode worms.

This clan contains 45 families and the total number of domains in the clan is 174162. The clan was built by M Fenech.


This clan contains the following 45 member families:

7TM-7TMR_HD 7tm_1 7tm_2 7tm_3 7tm_4 7TM_GPCR_Sra 7TM_GPCR_Srab 7TM_GPCR_Srb 7TM_GPCR_Srbc 7TM_GPCR_Srd 7TM_GPCR_Srh 7TM_GPCR_Sri 7TM_GPCR_Srj 7TM_GPCR_Srsx 7TM_GPCR_Srt 7TM_GPCR_Sru 7TM_GPCR_Srv 7TM_GPCR_Srw 7TM_GPCR_Srx 7TM_GPCR_Srz 7TM_GPCR_Str 7TMR-DISM_7TM Bac_rhodopsin Ceramidase Dicty_CAR DUF1182 DUF3522 DUF621 Frizzled Git3 GpcrRhopsn4 GPR_Gpa2_C Heliorhodopsin HisKA_7TM HlyIII Lung_7-TM_R Ocular_alb Per1 Pombe_5TM Serpentine_r_xa SID-1_RNA_chan Sre Srg TAS2R V1R

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
7tm_1 (PF00001) 56771 (32.6%) View
7tm_4 (PF13853) 37861 (21.7%) View
7tm_2 (PF00002) 11228 (6.4%) View
HlyIII (PF03006) 9670 (5.6%) View
7tm_3 (PF00003) 8807 (5.1%) View
7TMR-DISM_7TM (PF07695) 4115 (2.4%) View
7TM_GPCR_Str (PF10326) 3208 (1.8%) View
7TM_GPCR_Srw (PF10324) 3057 (1.8%) View
Lung_7-TM_R (PF06814) 2674 (1.5%) View
7TM_GPCR_Srx (PF10328) 2668 (1.5%) View
Frizzled (PF01534) 2547 (1.5%) View
7TM_GPCR_Srh (PF10318) 2346 (1.3%) View
HisKA_7TM (PF16927) 2234 (1.3%) View
Ceramidase (PF05875) 2194 (1.3%) View
V1R (PF03402) 1981 (1.1%) View
7TM-7TMR_HD (PF07698) 1745 (1.0%) View
Bac_rhodopsin (PF01036) 1667 (1.0%) View
7TM_GPCR_Srsx (PF10320) 1522 (0.9%) View
7TM_GPCR_Srt (PF10321) 1445 (0.8%) View
Per1 (PF04080) 1358 (0.8%) View
Git3 (PF11710) 1251 (0.7%) View
7TM_GPCR_Srd (PF10317) 1191 (0.7%) View
TAS2R (PF05296) 1115 (0.6%) View
Pfam family Num. domains Alignment
Sre (PF03125) 1042 (0.6%) View
7TM_GPCR_Srab (PF10292) 950 (0.5%) View
Srg (PF02118) 947 (0.5%) View
7TM_GPCR_Srv (PF10323) 937 (0.5%) View
GpcrRhopsn4 (PF10192) 855 (0.5%) View
Dicty_CAR (PF05462) 809 (0.5%) View
DUF3522 (PF12036) 803 (0.5%) View
SID-1_RNA_chan (PF13965) 741 (0.4%) View
7TM_GPCR_Sri (PF10327) 599 (0.3%) View
GPR_Gpa2_C (PF11970) 598 (0.3%) View
7TM_GPCR_Srz (PF10325) 582 (0.3%) View
7TM_GPCR_Srbc (PF10316) 574 (0.3%) View
7TM_GPCR_Sru (PF10322) 555 (0.3%) View
7TM_GPCR_Srj (PF10319) 393 (0.2%) View
7TM_GPCR_Sra (PF02117) 297 (0.2%) View
Ocular_alb (PF02101) 217 (0.1%) View
Heliorhodopsin (PF18761) 172 (0.1%) View
7TM_GPCR_Srb (PF02175) 140 (0.1%) View
Serpentine_r_xa (PF03383) 135 (0.1%) View
DUF621 (PF04789) 106 (0.1%) View
DUF1182 (PF06681) 43 (0.0%) View
Pombe_5TM (PF09437) 12 (0.0%) View
Total: 45 Total: 174162
No alignment ℹ

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 19 interactions for this clan. More...

Interacting families
7tm_1 7tm_1
7tm_2 Cytochrom_B562
Bac_rhodopsin Bac_rhodopsin
CXCR4_N 7tm_1
Cytochrom_B562 Frizzled
G-alpha 7tm_1
HRM 7tm_2
Phage_lysozyme 7tm_1
Rhodopsin_N 7tm_1
SRP19 7tm_1
SRP_SPB 7tm_1
WD40 7tm_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...