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983  structures 2142  species 29  interactions 73339  sequences 1482  architectures

Clan: GT-A (CL0110)


Glycosyl transferase clan GT-A Add an annotation

This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].

This clan contains 46 families and the total number of domains in the clan is 73339. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488


This clan contains the following 46 member families:

Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_15 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Osmo_MPGsynth Pox_P35 Rhamno_transf TcdA_TcdB UDPGP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glycos_transf_2 (PF00535) 22247 (30.3%) View
NTP_transferase (PF00483) 9547 (13.0%) View
NTP_transf_3 (PF12804) 3573 (4.9%) View
Glyco_tranf_2_3 (PF13641) 3533 (4.8%) View
Glyco_transf_8 (PF01501) 3524 (4.8%) View
Galactosyl_T (PF01762) 2993 (4.1%) View
Cellulose_synt (PF03552) 1764 (2.4%) View
Gly_transf_sug (PF04488) 1733 (2.4%) View
IspD (PF01128) 1700 (2.3%) View
CTP_transf_3 (PF02348) 1620 (2.2%) View
UDPGP (PF01704) 1532 (2.1%) View
Glyco_transf_7C (PF02709) 1246 (1.7%) View
Fringe (PF02434) 1199 (1.6%) View
Nucleotid_trans (PF03407) 1121 (1.5%) View
Chitin_synth_2 (PF03142) 1121 (1.5%) View
Glyco_transf_92 (PF01697) 1105 (1.5%) View
Mannosyl_trans3 (PF11051) 1057 (1.4%) View
Glyco_transf_15 (PF01793) 989 (1.3%) View
Glyco_trans_2_3 (PF13632) 977 (1.3%) View
Glyco_transf_49 (PF13896) 890 (1.2%) View
Glyco_transf_7N (PF13733) 857 (1.2%) View
Glyco_transf_34 (PF05637) 816 (1.1%) View
Glyco_transf_64 (PF09258) 813 (1.1%) View
CHGN (PF05679) 776 (1.1%) View
Pfam family Num. domains Alignment
Glyco_transf_43 (PF03360) 730 (1.0%) View
Chitin_synth_1 (PF01644) 680 (0.9%) View
Glyco_transf_25 (PF01755) 671 (0.9%) View
Glyco_transf_21 (PF13506) 558 (0.8%) View
Glyco_tranf_2_4 (PF13704) 537 (0.7%) View
DUF604 (PF04646) 534 (0.7%) View
Anp1 (PF03452) 530 (0.7%) View
GNT-I (PF03071) 427 (0.6%) View
DUF2064 (PF09837) 363 (0.5%) View
Glyco_transf_6 (PF03414) 325 (0.4%) View
GlcNAc (PF11397) 245 (0.3%) View
MGAT2 (PF05060) 223 (0.3%) View
Caps_synth (PF05704) 197 (0.3%) View
CofC (PF01983) 184 (0.3%) View
DUF273 (PF03314) 120 (0.2%) View
Glyco_tranf_2_5 (PF13712) 82 (0.1%) View
Glyco_tranf_2_2 (PF10111) 63 (0.1%) View
Rhamno_transf (PF11316) 59 (0.1%) View
Osmo_MPGsynth (PF09488) 38 (0.1%) View
TcdA_TcdB (PF12919) 19 (0.0%) View
Pox_P35 (PF03213) 11 (0.0%) View
CgtA (PF06306) 10 (0.0%) View
Total: 46 Total: 73339
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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