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713  structures 7680  species 17  interactions 127750  sequences 1496  architectures

Clan: GT-A (CL0110)


Glycosyl transferase clan GT-A Add an annotation

This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].

This clan contains 44 families and the total number of domains in the clan is 127750. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488


This clan contains the following 44 member families:

Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Pox_P35 Rhamno_transf TcdA_TcdB UDPGP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glycos_transf_2 (PF00535) 43678 (34.2%) View
NTP_transferase (PF00483) 22811 (17.9%) View
NTP_transf_3 (PF12804) 9345 (7.3%) View
Glyco_tranf_2_3 (PF13641) 8712 (6.8%) View
Glyco_transf_8 (PF01501) 5748 (4.5%) View
IspD (PF01128) 4492 (3.5%) View
CTP_transf_3 (PF02348) 4289 (3.4%) View
Glyco_trans_2_3 (PF13632) 2553 (2.0%) View
Galactosyl_T (PF01762) 2182 (1.7%) View
Glyco_transf_25 (PF01755) 1865 (1.5%) View
Gly_transf_sug (PF04488) 1796 (1.4%) View
UDPGP (PF01704) 1651 (1.3%) View
Cellulose_synt (PF03552) 1407 (1.1%) View
Glyco_transf_7C (PF02709) 1328 (1.0%) View
Chitin_synth_2 (PF03142) 1072 (0.8%) View
Fringe (PF02434) 1045 (0.8%) View
Glyco_tranf_2_4 (PF13704) 934 (0.7%) View
Chitin_synth_1 (PF01644) 884 (0.7%) View
Glyco_transf_92 (PF01697) 812 (0.6%) View
Glyco_transf_7N (PF13733) 775 (0.6%) View
Glyco_transf_49 (PF13896) 771 (0.6%) View
Mannosyl_trans3 (PF11051) 725 (0.6%) View
Nucleotid_trans (PF03407) 713 (0.6%) View
Pfam family Num. domains Alignment
Glyco_transf_21 (PF13506) 703 (0.6%) View
CHGN (PF05679) 643 (0.5%) View
Glyco_transf_64 (PF09258) 640 (0.5%) View
Glyco_transf_34 (PF05637) 639 (0.5%) View
Glyco_transf_6 (PF03414) 613 (0.5%) View
Glyco_transf_43 (PF03360) 602 (0.5%) View
DUF2064 (PF09837) 550 (0.4%) View
Glyco_tranf_2_2 (PF10111) 436 (0.3%) View
Anp1 (PF03452) 428 (0.3%) View
Caps_synth (PF05704) 400 (0.3%) View
TcdA_TcdB (PF12919) 376 (0.3%) View
GNT-I (PF03071) 372 (0.3%) View
Glyco_tranf_2_5 (PF13712) 312 (0.2%) View
DUF604 (PF04646) 290 (0.2%) View
CofC (PF01983) 277 (0.2%) View
GlcNAc (PF11397) 216 (0.2%) View
MGAT2 (PF05060) 200 (0.2%) View
CgtA (PF06306) 149 (0.1%) View
Pox_P35 (PF03213) 130 (0.1%) View
Rhamno_transf (PF11316) 99 (0.1%) View
DUF273 (PF03314) 87 (0.1%) View
Total: 44 Total: 127750 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 17 interactions for this clan. More...

Interacting families
Glyco_transf_64 Glyco_transf_64
IspD Hexapep
Glycos_transf_2 Ricin_B_lectin
Glyco_transf_34 Glyco_transf_34
Glyco_transf_7C Lys
NTP_transferase Hexapep
Glyco_transf_43 Glyco_transf_43
CofC CofC
Glyco_transf_8 Glyco_transf_8
CTP_transf_3 CTP_transf_3
Glyco_transf_6 Glyco_transf_6


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...