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1026  structures 3424  species 29  interactions 111154  sequences 1972  architectures

Clan: GT-A (CL0110)

Summary

Glycosyl transferase clan GT-A Add an annotation

This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].

This clan contains 46 families and the total number of domains in the clan is 111154. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488

Members

This clan contains the following 46 member families:

Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_15 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Osmo_MPGsynth Pox_P35 Rhamno_transf TcdA_TcdB UDPGP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glycos_transf_2 (PF00535) 35476 (31.9%) View
NTP_transferase (PF00483) 14914 (13.4%) View
Glyco_tranf_2_3 (PF13641) 5762 (5.2%) View
NTP_transf_3 (PF12804) 5428 (4.9%) View
Glyco_transf_8 (PF01501) 5167 (4.6%) View
Galactosyl_T (PF01762) 4003 (3.6%) View
Cellulose_synt (PF03552) 3029 (2.7%) View
CTP_transf_3 (PF02348) 2596 (2.3%) View
Gly_transf_sug (PF04488) 2511 (2.3%) View
IspD (PF01128) 2505 (2.3%) View
UDPGP (PF01704) 2244 (2.0%) View
Nucleotid_trans (PF03407) 1718 (1.5%) View
Glyco_trans_2_3 (PF13632) 1685 (1.5%) View
Chitin_synth_2 (PF03142) 1641 (1.5%) View
Fringe (PF02434) 1628 (1.5%) View
Glyco_transf_92 (PF01697) 1568 (1.4%) View
Mannosyl_trans3 (PF11051) 1549 (1.4%) View
Glyco_transf_7C (PF02709) 1414 (1.3%) View
Glyco_transf_15 (PF01793) 1360 (1.2%) View
Glyco_transf_34 (PF05637) 1244 (1.1%) View
Glyco_transf_49 (PF13896) 1168 (1.1%) View
Glyco_transf_64 (PF09258) 1051 (0.9%) View
Chitin_synth_1 (PF01644) 1036 (0.9%) View
Glyco_transf_43 (PF03360) 1008 (0.9%) View
continued
Pfam family Num. domains Alignment
Glyco_transf_7N (PF13733) 996 (0.9%) View
Glyco_transf_25 (PF01755) 884 (0.8%) View
CHGN (PF05679) 853 (0.8%) View
DUF604 (PF04646) 848 (0.8%) View
Glyco_tranf_2_4 (PF13704) 838 (0.8%) View
Glyco_transf_21 (PF13506) 783 (0.7%) View
Anp1 (PF03452) 781 (0.7%) View
GNT-I (PF03071) 590 (0.5%) View
DUF2064 (PF09837) 537 (0.5%) View
GlcNAc (PF11397) 436 (0.4%) View
Glyco_transf_6 (PF03414) 354 (0.3%) View
DUF273 (PF03314) 290 (0.3%) View
MGAT2 (PF05060) 290 (0.3%) View
Caps_synth (PF05704) 289 (0.3%) View
CofC (PF01983) 265 (0.2%) View
Rhamno_transf (PF11316) 103 (0.1%) View
Glyco_tranf_2_5 (PF13712) 102 (0.1%) View
Glyco_tranf_2_2 (PF10111) 92 (0.1%) View
TcdA_TcdB (PF12919) 46 (0.0%) View
Osmo_MPGsynth (PF09488) 46 (0.0%) View
CgtA (PF06306) 15 (0.0%) View
Pox_P35 (PF03213) 11 (0.0%) View
Total: 46 Total: 111154
No alignment ℹ
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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