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29  structures 17946  species 1  interaction 64846  sequences 411  architectures

Clan: GT-C (CL0111)


Glycosyl transferase GT-C superfamily Add an annotation

This is the GT-C clan that contains diverse glycosyltransferases that possess 8-13 predicted transmembrane segments [1].

This clan contains 19 families and the total number of domains in the clan is 64846. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488


This clan contains the following 19 member families:

ALG3 Alg6_Alg8 Arabinose_trans DIE2_ALG10 DUF2029 DUF2079 DUF2142 DUF2723 EpsG Glucan_synthase Glyco_transf_22 Mannosyl_trans Mannosyl_trans2 PIG-U PMT PMT_2 PTPS_related STT3 YfhO

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PMT_2 (PF13231) 12962 (20.0%) View
DUF2029 (PF09594) 11864 (18.3%) View
YfhO (PF09586) 8853 (13.7%) View
PMT (PF02366) 8381 (12.9%) View
Arabinose_trans (PF04602) 5745 (8.9%) View
EpsG (PF14897) 2740 (4.2%) View
Glyco_transf_22 (PF03901) 2401 (3.7%) View
Glucan_synthase (PF02364) 1706 (2.6%) View
STT3 (PF02516) 1659 (2.6%) View
Alg6_Alg8 (PF03155) 1390 (2.1%) View
DUF2142 (PF09913) 1129 (1.7%) View
Mannosyl_trans2 (PF04188) 961 (1.5%) View
DUF2079 (PF09852) 903 (1.4%) View
DUF2723 (PF11028) 861 (1.3%) View
PIG-U (PF06728) 690 (1.1%) View
DIE2_ALG10 (PF04922) 683 (1.1%) View
Mannosyl_trans (PF05007) 663 (1.0%) View
ALG3 (PF05208) 656 (1.0%) View
PTPS_related (PF10131) 599 (0.9%) View
Total: 19 Total: 64846 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
Arabinose_trans Arabinose_trans


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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