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428  structures 7661  species 13  interactions 28461  sequences 109  architectures

Clan: GlnB-like (CL0089)


GlnB-like superfamily Add an annotation

The members of this clan are characterised by the fact the domains, each comprised of four beta-strand and two alpha helices, tend to form tetrameric structures [1].

This clan contains 12 families and the total number of domains in the clan is 28461. The clan was built by RD Finn.

Literature references

  1. Cho Y, Sharma V, Sacchettini JC; , J Biol Chem 2003;278:8333-8339.: Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis. PUBMED:12511575 EPMC:12511575


This clan contains the following 12 member families:

Amidase02_C CdAMP_rec CutA1 DUF190 DUF2007 DUF2179 DUF3240 HisG_C Nit_Regul_Hom NRho P-II Rhomboid_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
P-II (PF00543) 9190 (32.3%) View
DUF2179 (PF10035) 6599 (23.2%) View
HisG_C (PF08029) 3746 (13.2%) View
CutA1 (PF03091) 2924 (10.3%) View
DUF2007 (PF09413) 2680 (9.4%) View
DUF190 (PF02641) 1414 (5.0%) View
CdAMP_rec (PF06153) 1140 (4.0%) View
Rhomboid_N (PF12122) 336 (1.2%) View
NRho (PF16733) 189 (0.7%) View
DUF3240 (PF11582) 185 (0.7%) View
Amidase02_C (PF12123) 39 (0.1%) View
Nit_Regul_Hom (PF10126) 19 (0.1%) View
Total: 12 Total: 28461 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
AA_kinase P-II
ADP_ribosyl_GH P-II
Amidase02_C Amidase02_C
Ammonium_transp P-II
CdAMP_rec CdAMP_rec
CutA1 CutA1
DUF190 DUF190
DUF2179 DUF2179
HisG HisG_C
P-II DUF3539
Rhomboid Rhomboid_N
Rhomboid_N Rhomboid


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...