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429  structures 23485  species 28  interactions 258659  sequences 546  architectures

Clan: Glutaminase_I (CL0014)


Class-I Glutamine amidotransferase superfamily Add an annotation

Most members of this clan are glutaminase enzymes. This superfamily is shown to be related in [1]. The clan also contains the DJ-1/PfpI family that includes the peptidase PfpI that has a catalytic Cys-His-Glu triad that differs from the class I GAT Cys-His-Glu triad.

This clan contains 14 families and the total number of domains in the clan is 258659. The clan was built by A Bateman.

Literature references

  1. Galperin MY, Grishin NV; , Proteins 2000;41:238-247.: The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase. PUBMED:10966576 EPMC:10966576


This clan contains the following 14 member families:

BPL_N DJ-1_PfpI DUF4159 GATase GATase1_like GATase_3 GATase_5 Glyco_hydro_42M HTS Peptidase_C26 Peptidase_S51 SNO ThiJ_like ThuA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GATase (PF00117) 118476 (45.8%) View
DJ-1_PfpI (PF01965) 55356 (21.4%) View
GATase_3 (PF07685) 22052 (8.5%) View
GATase_5 (PF13507) 18992 (7.3%) View
Peptidase_C26 (PF07722) 10737 (4.2%) View
SNO (PF01174) 8949 (3.5%) View
HTS (PF04204) 6945 (2.7%) View
Peptidase_S51 (PF03575) 5937 (2.3%) View
GATase1_like (PF07090) 3202 (1.2%) View
ThuA (PF06283) 2658 (1.0%) View
Glyco_hydro_42M (PF08532) 2562 (1.0%) View
ThiJ_like (PF17124) 997 (0.4%) View
DUF4159 (PF13709) 973 (0.4%) View
BPL_N (PF09825) 823 (0.3%) View
Total: 14 Total: 258659 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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