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0  structures 2301  species 0  interactions 7226  sequences 44  architectures

Clan: Glycine-zipper (CL0500)


Glycine-zipper TM superfamily Add an annotation

This superfamily is characterised by having long glycine-zipper motifs, characteristically GxxxGxxxG [1], often with several contiguous copies. The x following the G is frequently found to be an alanine. This sequence region can be found in both symmetric and non-symmetrical membrane structures, and is relatively common. The fact that such a large fraction of the relatively few known membrane channel structures use the glycine zipper suggests that the sequence motif plays a special role in forming these homo-oligomeric bundles [1].

This clan contains 5 families and the total number of domains in the clan is 7226. The clan was built by P Coggill.

Literature references

  1. Kim S, Jeon TJ, Oberai A, Yang D, Schmidt JJ, Bowie JU;, Proc Natl Acad Sci U S A. 2005;102:14278-14283.: Transmembrane glycine zippers: physiological and pathological roles in membrane proteins. PUBMED:16179394 EPMC:16179394


This clan contains the following 5 member families:

DUF1269 Gly-zipper_Omp Gly-zipper_OmpA Gly-zipper_YMGG Rick_17kDa_Anti

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rick_17kDa_Anti (PF05433) 3882 (53.7%) View
Gly-zipper_Omp (PF13488) 2160 (29.9%) View
Gly-zipper_YMGG (PF13441) 420 (5.8%) View
DUF1269 (PF06897) 415 (5.7%) View
Gly-zipper_OmpA (PF13436) 349 (4.8%) View
Total: 5 Total: 7226 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...