Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
143  structures 1023  species 10  interactions 24465  sequences 625  architectures

Clan: Golgi-transport (CL0145)


Golgi-transport Add an annotation

This clan contains families that are involved in intracellular transport and signalling. Arfaptins are proteins which interact with small GTPases involved in vesicular budding at the Golgi complex. They form an elongated dimer of three helix coiled coils and are structurally very similar to the BAR domain [1][2]. The Sec34 family is involved in tethering vesicles to the Golgi [3].

This clan contains 9 families and the total number of domains in the clan is 24465. The clan was built by J Mistry.

Literature references

  1. Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ; , Nature 2001;411:215-219.: The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. PUBMED:11346801 EPMC:11346801
  2. Habermann B; , EMBO Rep 2004;5:250-255.: The BAR-domain family of proteins: a case of bending and binding?. PUBMED:14993925 EPMC:14993925
  3. Whyte JR, Munro S; , Dev Cell 2001;1:527-537.: The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. PUBMED:11703943 EPMC:11703943


This clan contains the following 9 member families:

Arfaptin BAR BAR_2 BAR_3 BAR_3_WASP_bdg FAM92 FCH IMD Vps5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FCH (PF00611) 6389 (26.1%) View
BAR (PF03114) 5990 (24.5%) View
BAR_3 (PF16746) 3903 (16.0%) View
Vps5 (PF09325) 3108 (12.7%) View
Arfaptin (PF06456) 1591 (6.5%) View
IMD (PF08397) 1587 (6.5%) View
BAR_3_WASP_bdg (PF10456) 757 (3.1%) View
BAR_2 (PF10455) 644 (2.6%) View
FAM92 (PF06730) 496 (2.0%) View
Total: 9 Total: 24465 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
Arf Arfaptin
Arfaptin Arfaptin
BAR_3_WASP_bdg BAR_3_WASP_bdg


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...