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125  structures 3114  species 14  interactions 9343  sequences 1237  architectures

Clan: H-int (CL0363)


Hedgehog/intein (Hint) superfamily Add an annotation

This superfamily includes Hedgehog C-terminal (Hog) autoprocessing domain and Intein (protein splicing domain) families.

This clan contains 7 families and the total number of domains in the clan is 9343. The clan was built by A Bateman.


This clan contains the following 7 member families:

Hint Hint_2 Hom_end_hint Intein_splicing PT-HINT U6-snRNA_bdg Vint

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hint_2 (PF13403) 3245 (34.7%) View
Intein_splicing (PF14890) 2101 (22.5%) View
U6-snRNA_bdg (PF10596) 1339 (14.3%) View
PT-HINT (PF07591) 1127 (12.1%) View
Hint (PF01079) 1082 (11.6%) View
Vint (PF14623) 251 (2.7%) View
Hom_end_hint (PF05203) 198 (2.1%) View
Total: 7 Total: 9343 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
AAR2 U6-snRNA_bdg
ATP-synt_ab Hom_end_hint
DNA_pol_B Intein_splicing
DnaB_C Intein_splicing
HH_signal Hint
Hom_end Hom_end_hint
Hom_end_hint ATP-synt_ab
Intein_splicing DNA_pol_B
RRM_4 U6-snRNA_bdg
U5_2-snRNA_bdg U6-snRNA_bdg
U6-snRNA_bdg PRP8_domainIV


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...