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1231  structures 5425  species 34  interactions 145151  sequences 1741  architectures

Clan: HAD (CL0137)

Summary

HAD superfamily Add an annotation

This clan represents the haloacid dehalogenase (HAD) superfamily that includes a diverse range of enzymes that use an asp carboxylate as a nucleophile [1].

This clan contains 23 families and the total number of domains in the clan is 145151. The clan was built by A Bateman.

Literature references

  1. Koonin EV, Tatusov RL; , J Mol Biol 1994;244:125-132.: Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. PUBMED:7966317 EPMC:7966317
  2. Aravind L, Galperin MY, Koonin EV; , Trends Biochem Sci 1998;23:127-129.: The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold. PUBMED:9584613 EPMC:9584613

Members

This clan contains the following 23 member families:

5_nucleotid Acid_phosphat_B Acid_PPase Cation_ATPase DHH DUF2608 DUF705 HAD HAD_2 Hydrolase Hydrolase_3 Hydrolase_6 Hydrolase_like LNS2 NIF NT5C PGP_phosphatase PMM PNK3P Put_Phosphatase S6PP Trehalose_PPase UMPH-1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hydrolase (PF00702) 34088 (23.5%) View
HAD_2 (PF13419) 31382 (21.6%) View
Hydrolase_3 (PF08282) 13134 (9.0%) View
Cation_ATPase (PF13246) 10992 (7.6%) View
DHH (PF01368) 9451 (6.5%) View
Hydrolase_like (PF13242) 8887 (6.1%) View
HAD (PF12710) 7910 (5.4%) View
NIF (PF03031) 6915 (4.8%) View
Hydrolase_6 (PF13344) 5846 (4.0%) View
Trehalose_PPase (PF02358) 4245 (2.9%) View
5_nucleotid (PF05761) 1601 (1.1%) View
Acid_phosphat_B (PF03767) 1482 (1.0%) View
continued
Pfam family Num. domains Alignment
LNS2 (PF08235) 1364 (0.9%) View
PMM (PF03332) 1323 (0.9%) View
PNK3P (PF08645) 1250 (0.9%) View
S6PP (PF05116) 1187 (0.8%) View
NT5C (PF06941) 954 (0.7%) View
Put_Phosphatase (PF06888) 804 (0.6%) View
Acid_PPase (PF12689) 778 (0.5%) View
UMPH-1 (PF05822) 711 (0.5%) View
PGP_phosphatase (PF09419) 708 (0.5%) View
DUF2608 (PF11019) 123 (0.1%) View
DUF705 (PF05152) 16 (0.0%) View
Total: 23 Total: 145151 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 34 interactions for this clan. More...

Interacting families
A B
AAA_33 PNK3P
Acid_phosphat_B Acid_phosphat_B
Acid_PPase Acid_PPase
Cation_ATPase_N Hydrolase
CBS DHH
DHH CBS
DHH
DHHA1
DHHA2
DRTGG
DHHA2 DHH
DRTGG DHH
E1-E2_ATPase Hydrolase
HAD HAD
HAD_2 HAD_2
HMA Hydrolase
Hydrolase Cation_ATPase_C
E1-E2_ATPase
Hydrolase
Hydrolase_3 Hydrolase_3
Hydrolase_6 Hydrolase_6
Hydrolase_like
Hydrolase_like Hydrolase_6
Hydrolase_like
NIF NIF
PTCB-BRCT
RNA_pol_Rpb1_R
NT5C NT5C
PMM PMM
PNK3P AAA_33
PNK3P
S6PP S6PP
ubiquitin NIF
UMPH-1 UMPH-1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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