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488  structures 27616  species 20  interactions 61581  sequences 88  architectures

Clan: HAS-barrel (CL0275)

Summary

HAS-barrel superfamily Add an annotation

The HAS barrel is named after HerA-ATP Synthase. In ATP synthases, this domain is implicated in the assembly of the catalytic toroid and docking of accessory subunits, such as the subunit of the ATP synthase complex. Similar roles in docking of the functional partner, the NurA nuclease, and assembly of the HerA toroid complex appear likely for the HAS-barrel of the HerA family [1].

This clan contains 2 families and the total number of domains in the clan is 61581. The clan was built by A Bateman.

Literature references

  1. Iyer LM, Makarova KS, Koonin EV, Aravind L; , Nucleic Acids Res. 2004;32:5260-5279.: Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. PUBMED:15466593 EPMC:15466593

Members

This clan contains the following 2 member families:

ATP-synt_ab_N HAS-barrel

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ATP-synt_ab_N (PF02874) 61020 (99.1%) View
HAS-barrel (PF09378) 561 (0.9%) View
Total: 2 Total: 61581 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 20 interactions for this clan. More...

Interacting families
A B
ATP-synt ATP-synt_ab_N
ATP-synt_ab ATP-synt_ab_N
ATP-synt_ab_C ATP-synt_ab_N
ATP-synt_ab_N ATP-synt
ATP-synt_ab
ATP-synt_ab_C
ATP-synt_ab_N
ATP-synt_DE
ATP-synt_DE_N
ATP-synt_F6
HAS-barrel
Mt_ATP-synt_B
OSCP
vATP-synt_E
ATP-synt_DE_N ATP-synt_ab_N
HAS-barrel ATP-synt
ATP-synt_ab
ATP-synt_ab_N
ATP-synt_DE
HAS-barrel

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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