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856  structures 21851  species 67  interactions 322733  sequences 777  architectures

Clan: HHH (CL0198)

Summary

Helix-hairpin-helix superfamily Add an annotation

This superfamily includes Helix-hairpin-helix DNA-binding domains.

This clan contains 20 families and the total number of domains in the clan is 322733. The clan was built by A Bateman.

Literature references

  1. Doherty AJ, Serpell LC, Ponting CP; , Nucleic Acids Res 1996;24:2488-2497.: The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. PUBMED:8692686 EPMC:8692686
  2. Shao X, Grishin NV; , Nucleic Acids Res 2000;28:2643-2650.: Common fold in helix-hairpin-helix proteins. PUBMED:10908318 EPMC:10908318

Members

This clan contains the following 20 member families:

Cdd1 DNA_pol_lambd_f DUF3173 DUF4332 DUF655 HHH HhH-GPD HHH_2 HHH_3 HHH_4 HHH_5 HHH_6 HHH_7 HHH_8 IMS_HHH PsbU RNA_pol_A_CTD T2SSK TfoX_C Transposase_20

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HhH-GPD (PF00730) 56495 (17.5%) View
HHH_5 (PF14520) 39835 (12.3%) View
HHH_3 (PF12836) 34718 (10.8%) View
HHH (PF00633) 34608 (10.7%) View
HHH_6 (PF14579) 31281 (9.7%) View
Transposase_20 (PF02371) 27156 (8.4%) View
HHH_2 (PF12826) 23114 (7.2%) View
RNA_pol_A_CTD (PF03118) 21776 (6.7%) View
IMS_HHH (PF11798) 21403 (6.6%) View
HHH_4 (PF14490) 8472 (2.6%) View
HHH_8 (PF14716) 8280 (2.6%) View
T2SSK (PF03934) 5756 (1.8%) View
TfoX_C (PF04994) 5011 (1.6%) View
DUF3173 (PF11372) 1553 (0.5%) View
DNA_pol_lambd_f (PF10391) 965 (0.3%) View
Cdd1 (PF11731) 684 (0.2%) View
HHH_7 (PF14635) 595 (0.2%) View
DUF4332 (PF14229) 561 (0.2%) View
DUF655 (PF04919) 312 (0.1%) View
PsbU (PF06514) 158 (0.0%) View
Total: 20 Total: 322733 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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