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165  structures 7401  species 9  interactions 16630  sequences 209  architectures

Clan: HRDC-like (CL0426)


HRDC-like superfamily Add an annotation

Superfamily includes HRDC domain from helicases, RNA polymerase II subunit RBP4, RNase D C-terminal domains, and EXOSC10 HRDC domain-like families.

This clan contains 4 families and the total number of domains in the clan is 16630. The clan was built by P Coggill.


This clan contains the following 4 member families:

DNA_pol_A_exoN Helicase_Sgs1 HRDC RNA_pol_Rpb4

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HRDC (PF00570) 12993 (78.1%) View
RNA_pol_Rpb4 (PF03874) 2488 (15.0%) View
DNA_pol_A_exoN (PF18305) 1104 (6.6%) View
Helicase_Sgs1 (PF11408) 45 (0.3%) View
Total: 4 Total: 16630 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 9 interactions for this clan. More...

Interacting families
DNA_pol_A_exo1 HRDC
RNA_pol_Rpb1_1 RNA_pol_Rpb4
RNA_pol_Rpb4 RNA_pol_Rbc25
S1 RNA_pol_Rpb4
SHS2_Rpb7-N RNA_pol_Rpb4


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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