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23  structures 342  species 2  interactions 4684  sequences 249  architectures

Clan: Hect (CL0552)

Summary

Hect, E3 ligase catalytic domain Add an annotation

This superfamily is characterised by fmailies with E3-ligase catalytic acitvity. The fold consists of two alpha+beta domains; where the N-terminal domain is an array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit.

This clan contains 2 families and the total number of domains in the clan is 4684. The clan was built by P Coggill.

Literature references

  1. Kobirumaki F, Miyauchi Y, Fukami K, Tanaka H;, J Biochem. 2005;137:133-139.: A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro. PUBMED:15749827 EPMC:15749827

Members

This clan contains the following 2 member families:

HECT HECT_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HECT (PF00632) 4368 (93.3%) View
HECT_2 (PF09814) 316 (6.7%) View
Total: 2 Total: 4684 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
HECT UQ_con
HECT

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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