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176  structures 20204  species 15  interactions 94794  sequences 709  architectures

Clan: His-Me_finger (CL0263)

Summary

His-Me finger endonuclease superfamily Add an annotation

This superfamily defined originally by SCOP contains a diverse range of endonucleases. Later Grishin identified the MH1 domain as belonging to the superfamily [1].

This clan contains 22 families and the total number of domains in the clan is 94794. The clan was built by A Bateman.

Literature references

  1. Grishin NV; , J Mol Biol. 2001;307:31-37.: Mh1 domain of Smad is a degraded homing endonuclease. PUBMED:11243801 EPMC:11243801

Members

This clan contains the following 22 member families:

AHH Colicin-DNase DUF1524 DUF968 Endonuclea_NS_2 Endonuclease_1 Endonuclease_7 Endonuclease_NS GH-E HNH HNH_2 HNH_3 HNH_4 HNH_5 HNHc_6 ICEA LHH MH1 NinG RecA_dep_nuc WHH zf-His_Me_endon

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HNH (PF01844) 33198 (35.0%) View
DUF1524 (PF07510) 8527 (9.0%) View
Endonuclease_NS (PF01223) 7257 (7.7%) View
Endonuclea_NS_2 (PF13930) 6436 (6.8%) View
DUF968 (PF06147) 6092 (6.4%) View
Endonuclease_1 (PF04231) 5508 (5.8%) View
HNH_2 (PF13391) 5235 (5.5%) View
HNHc_6 (PF16784) 4705 (5.0%) View
HNH_3 (PF13392) 4543 (4.8%) View
NinG (PF05766) 2875 (3.0%) View
Colicin-DNase (PF12639) 2581 (2.7%) View
HNH_4 (PF13395) 2293 (2.4%) View
continued
Pfam family Num. domains Alignment
MH1 (PF03165) 1869 (2.0%) View
WHH (PF14414) 823 (0.9%) View
AHH (PF14412) 805 (0.8%) View
Endonuclease_7 (PF02945) 550 (0.6%) View
HNH_5 (PF14279) 383 (0.4%) View
LHH (PF14411) 323 (0.3%) View
RecA_dep_nuc (PF16786) 292 (0.3%) View
GH-E (PF14410) 223 (0.2%) View
ICEA (PF05315) 187 (0.2%) View
zf-His_Me_endon (PF05551) 89 (0.1%) View
Total: 22 Total: 94794 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 15 interactions for this clan. More...

Interacting families
A B
Colicin-DNase Colicin-DNase
Colicin_Pyocin
Colicin_Pyocin Colicin-DNase
Endonuc-dimeris Endonuclease_7
Endonuclea_NS_2 Endonuclea_NS_2
Endonuclease_1 Endonuclease_1
Endonuclease_7 Endonuc-dimeris
Endonuclease_7
Endonuclease_NS Endonuclease_NS
Ku_PK_bind
NuiA
MH1 MH1
NUMOD4 HNH_3
Phosphodiest Endonuclease_NS
zf-His_Me_endon zf-His_Me_endon

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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