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1300  structures 14055  species 27  interactions 38487  sequences 263  architectures

Clan: Histone (CL0012)

Summary

Histone superfamily Add an annotation

Members of this clan all possess a histone fold. Generally proteins in this clan are DNA binding.

This clan contains 13 families and the total number of domains in the clan is 38487. The clan was built by A Bateman.

Members

This clan contains the following 13 member families:

Bromo_TP Bromo_TP_like CBFD_NFYB_HMF CENP-S CENP-T_C CENP-W CENP-X Histone TAF TAFII28 TFIID-18kDa TFIID-31kDa TFIID_20kDa

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Histone (PF00125) 25449 (66.1%) View
CBFD_NFYB_HMF (PF00808) 5303 (13.8%) View
CENP-T_C (PF15511) 1814 (4.7%) View
Bromo_TP (PF07524) 1206 (3.1%) View
TFIID-18kDa (PF02269) 1084 (2.8%) View
TAF (PF02969) 729 (1.9%) View
TFIID-31kDa (PF02291) 683 (1.8%) View
TFIID_20kDa (PF03847) 666 (1.7%) View
TAFII28 (PF04719) 627 (1.6%) View
CENP-S (PF15630) 428 (1.1%) View
CENP-X (PF09415) 354 (0.9%) View
CENP-W (PF15510) 119 (0.3%) View
Bromo_TP_like (PF17027) 25 (0.1%) View
Total: 13 Total: 38487 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 27 interactions for this clan. More...

Interacting families
A B
ASF1_hist_chap Histone
CAF1C_H4-bd Histone
CBFB_NFYA CBFD_NFYB_HMF
CBFD_NFYB_HMF CBFD_NFYB_HMF
TBP
CENP-S CENP-S
CENP-X
CENP-X CENP-X
Daxx Histone
Histone BAH
CHZ
Daxx
Histone
PH
RhoGEF
Scm3
MHC_I Histone
Scm3 Histone
SET Histone
SIR2 Histone
TAF4 TFIID_20kDa
TFIID-18kDa TAFII28
TFIID-31kDa CENP-X
TAF
TFIID_20kDa TAF4
TFIID_20kDa
WD40 Histone

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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