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139  structures 11316  species 15  interactions 28066  sequences 405  architectures

Clan: Homing_endonuc (CL0324)

Summary

Homing endonuclease-like superfamily Add an annotation

This superfamily includes a variety of LAGLIDADG-like homing endonuclease like families.

This clan contains 7 families and the total number of domains in the clan is 28066. The clan was built by A Bateman.

Literature references

  1. Stoddard BL; , Q Rev Biophys. 2005;38:49-95.: Homing endonuclease structure and function. PUBMED:16336743 EPMC:16336743

Members

This clan contains the following 7 member families:

Endonuc_subdom Hom_end LAGLIDADG_1 LAGLIDADG_2 LAGLIDADG_3 LAGLIDADG_WhiA WhiA_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LAGLIDADG_WhiA (PF14527) 10325 (36.8%) View
WhiA_N (PF10298) 9929 (35.4%) View
LAGLIDADG_3 (PF14528) 4735 (16.9%) View
LAGLIDADG_1 (PF00961) 2201 (7.8%) View
LAGLIDADG_2 (PF03161) 539 (1.9%) View
Hom_end (PF05204) 332 (1.2%) View
Endonuc_subdom (PF09062) 5 (0.0%) View
Total: 7 Total: 28066 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 15 interactions for this clan. More...

Interacting families
A B
ATP-synt_ab Hom_end
Endonuc_subdom LAGLIDADG_3
Stirrup
Hom_end ATP-synt_ab
Hom_end
Hom_end_hint
Hom_end_hint Hom_end
Intein_splicing LAGLIDADG_3
LAGLIDADG_1 LAGLIDADG_1
LAGLIDADG_2 LAGLIDADG_2
LAGLIDADG_3 LAGLIDADG_3
Ribonuc_red_lgC
Stirrup
WhiA_N LAGLIDADG_WhiA
WhiA_N

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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