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359  structures 20061  species 13  interactions 224548  sequences 263  architectures

Clan: ISOCOT_Fold (CL0246)


Isomerase,CoA transferase & Translation initiation factor Superfamily Add an annotation

This superfamily contains a variety of enzymes and non-enzymatic ligand binding domains.

This clan contains 12 families and the total number of domains in the clan is 224548. The clan was built by A Bateman and V Anantharaman.

Literature references

  1. Anantharaman V, Aravind L;, J Mol Biol. 2006;356:823-842.: Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. PUBMED:16376935 EPMC:16376935


This clan contains the following 12 member families:

5-FTHF_cyc-lig AcetylCoA_hyd_C AcetylCoA_hydro CitF CoA_trans DeoRC DUF162 Glucosamine_iso IF-2B Mal_decarbox_Al Rib_5-P_isom_A Sugar-bind

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DeoRC (PF00455) 68434 (30.5%) View
CoA_trans (PF01144) 36377 (16.2%) View
Glucosamine_iso (PF01182) 24694 (11.0%) View
5-FTHF_cyc-lig (PF01812) 19491 (8.7%) View
Sugar-bind (PF04198) 17531 (7.8%) View
Rib_5-P_isom_A (PF06026) 15303 (6.8%) View
DUF162 (PF02589) 12183 (5.4%) View
AcetylCoA_hyd_C (PF13336) 8328 (3.7%) View
AcetylCoA_hydro (PF02550) 7870 (3.5%) View
IF-2B (PF01008) 6961 (3.1%) View
CitF (PF04223) 5419 (2.4%) View
Mal_decarbox_Al (PF16957) 1957 (0.9%) View
Total: 12 Total: 224548 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
5-FTHF_cyc-lig 5-FTHF_cyc-lig
AcetylCoA_hyd_C AcetylCoA_hyd_C
AcetylCoA_hydro AcetylCoA_hyd_C
CitF CitF
CoA_trans CoA_trans
Glucosamine_iso Glucosamine_iso
HTH_38 Sugar-bind
Rib_5-P_isom_A Rib_5-P_isom_A
Sugar-bind HTH_38


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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