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279  structures 5233  species 11  interactions 53370  sequences 161  architectures

Clan: ISOCOT_Fold (CL0246)


Isomerase,CoA transferase & Translation initiation factor Superfamily Add an annotation

This superfamily contains a variety of enzymes and non-enzymatic ligand binding domains.

This clan contains 11 families and the total number of domains in the clan is 53370. The clan was built by A Bateman and V Anantharaman.

Literature references

  1. Anantharaman V, Aravind L;, J Mol Biol. 2006;356:823-842.: Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. PUBMED:16376935 EPMC:16376935


This clan contains the following 11 member families:

5-FTHF_cyc-lig AcetylCoA_hyd_C AcetylCoA_hydro CitF CoA_trans DeoRC DUF162 Glucosamine_iso IF-2B Rib_5-P_isom_A Sugar-bind

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DeoRC (PF00455) 14356 (26.9%) View
CoA_trans (PF01144) 6881 (12.9%) View
Glucosamine_iso (PF01182) 6449 (12.1%) View
5-FTHF_cyc-lig (PF01812) 4810 (9.0%) View
DUF162 (PF02589) 4142 (7.8%) View
Sugar-bind (PF04198) 3935 (7.4%) View
Rib_5-P_isom_A (PF06026) 3557 (6.7%) View
IF-2B (PF01008) 3047 (5.7%) View
AcetylCoA_hydro (PF02550) 2652 (5.0%) View
AcetylCoA_hyd_C (PF13336) 2410 (4.5%) View
CitF (PF04223) 1131 (2.1%) View
Total: 11 Total: 53370 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
CitF CitF
Glucosamine_iso Glucosamine_iso
5-FTHF_cyc-lig 5-FTHF_cyc-lig
CoA_trans CoA_trans
DUF162 DUF162
DeoRC Rib_5-P_isom_A
AcetylCoA_hydro AcetylCoA_hydro
Rib_5-P_isom_A DeoRC
Sugar-bind Sugar-bind


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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