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517  structures 6746  species 21  interactions 36906  sequences 287  architectures

Clan: ISP-domain (CL0516)


Rieske-like iron-sulphur domain Add an annotation

This superfamily is characterised by Rieske Iron-sulfur families of the [2Fe-2S] type including NADH-nitrite reductase small subunit NirD proteins. This domain has an all-beta rubredoxin-like fold.

This clan contains 3 families and the total number of domains in the clan is 36906. The clan was built by P Coggill.


This clan contains the following 3 member families:

Rieske Rieske_2 Rieske_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rieske (PF00355) 33574 (91.0%) View
Rieske_2 (PF13806) 3191 (8.6%) View
Rieske_3 (PF18465) 141 (0.4%) View
Total: 3 Total: 36906 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 21 interactions for this clan. More...

Interacting families
Aromatic_hydrox Rieske
CytB6-F_Fe-S Rieske
Cytochrom_B_C Rieske
Cytochrom_B_N_2 Rieske
Cytochrom_C1 Rieske
Molybdopterin Rieske
Molydop_binding Rieske
Pyr_redox_2 Rieske
Reductase_C Rieske
Rieske Aromatic_hydrox
Rieske_2 Rieske_2
Ring_hydroxyl_A Rieske
Ring_hydroxyl_B Rieske
UCR_hinge Rieske


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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