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26  structures 7589  species 0  interactions 75809  sequences 301  architectures

Clan: IT (CL0182)


IT (Ion Transporter) superfamily Add an annotation

This superfamily of secondary carriers specific for cationic and anionic compounds, has been termed the ion transporter (IT) superfamily [1].

This clan contains 19 families and the total number of domains in the clan is 75809. The clan was built by A Bateman.

Literature references

  1. Prakash S, Cooper G, Singhi S, Saier MH Jr; , Biochim Biophys Acta 2003;1618:79-92.: The ion transporter superfamily. PUBMED:14643936 EPMC:14643936


This clan contains the following 19 member families:

ABG_transport ArsB CitMHS CitMHS_2 DctM DcuA_DcuB DcuC DUF1646 DUF401 EXS GntP_permease Lactate_perm MatC_N Na_H_antiport_2 Na_H_antiport_3 Na_H_antiporter Na_sulph_symp NhaB SCFA_trans

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DctM (PF06808) 22267 (29.4%) View
CitMHS (PF03600) 12690 (16.7%) View
Na_H_antiporter (PF03553) 8804 (11.6%) View
Na_sulph_symp (PF00939) 8049 (10.6%) View
GntP_permease (PF02447) 5265 (6.9%) View
EXS (PF03124) 3812 (5.0%) View
Lactate_perm (PF02652) 2928 (3.9%) View
DcuC (PF03606) 2561 (3.4%) View
ArsB (PF02040) 2134 (2.8%) View
ABG_transport (PF03806) 1740 (2.3%) View
SCFA_trans (PF02667) 1209 (1.6%) View
DcuA_DcuB (PF03605) 1130 (1.5%) View
Na_H_antiport_2 (PF13726) 856 (1.1%) View
CitMHS_2 (PF16980) 646 (0.9%) View
MatC_N (PF07158) 629 (0.8%) View
NhaB (PF06450) 462 (0.6%) View
Na_H_antiport_3 (PF07399) 291 (0.4%) View
DUF401 (PF04165) 207 (0.3%) View
DUF1646 (PF07854) 129 (0.2%) View
Total: 19 Total: 75809 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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