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5458  structures 8427  species 229  interactions 180676  sequences 5477  architectures

Clan: Ig (CL0011)

Summary

Immunoglobulin superfamily Add an annotation

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The superfamily can be divided into discrete structural sets, by the presence or absence of beta-strands in the structure and the length of the domains [1]. Proteins containing domains of the C1 and V-sets are mostly molecules of the vertebrate immune system. Proteins of the C2-set are mainly lymphocyte antigens, this differs from the composition of the C2-set as originally proposed [1]. The I-set is intermediate in structure between the C1 and V-sets and is found widely in cell surface proteins as well as intracellular muscle proteins.

This clan contains 28 families and the total number of domains in the clan is 180676. The clan was built by A Bateman and RD Finn.

Literature references

  1. Williams AF, Barclay AN; , Annu Rev Immunol 1988;6:381-405.: The immunoglobulin superfamily--domains for cell surface recognition. PUBMED:3289571 EPMC:3289571
  2. Harpaz Y, Chothia C; , J Mol Biol 1994;238:528-539.: Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. PUBMED:8176743 EPMC:8176743

Members

This clan contains the following 28 member families:

A2M Adeno_E3_CR1 Adhes-Ig_like C1-set C2-set C2-set_2 Herpes_gE Herpes_gI Herpes_glycop_D I-set ICAM_N ig Ig_2 Ig_3 Ig_4 Ig_5 Ig_Tie2_1 Izumo-Ig K1 Lep_receptor_Ig Marek_A PTCRA Receptor_2B4 SVA UL141 V-set V-set_2 V-set_CD47

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
I-set (PF07679) 84215 (46.6%) View
V-set (PF07686) 23976 (13.3%) View
C1-set (PF07654) 22137 (12.3%) View
Ig_3 (PF13927) 12433 (6.9%) View
Ig_2 (PF13895) 12360 (6.8%) View
A2M (PF00207) 9112 (5.0%) View
ig (PF00047) 6902 (3.8%) View
C2-set_2 (PF08205) 4709 (2.6%) View
K1 (PF02960) 970 (0.5%) View
Lep_receptor_Ig (PF06328) 439 (0.2%) View
Adeno_E3_CR1 (PF02440) 422 (0.2%) View
C2-set (PF05790) 392 (0.2%) View
Herpes_gE (PF02480) 382 (0.2%) View
Marek_A (PF02124) 355 (0.2%) View
Herpes_glycop_D (PF01537) 348 (0.2%) View
continued
Pfam family Num. domains Alignment
ICAM_N (PF03921) 315 (0.2%) View
Herpes_gI (PF01688) 191 (0.1%) View
Ig_4 (PF16680) 179 (0.1%) View
V-set_CD47 (PF08204) 163 (0.1%) View
V-set_2 (PF15910) 146 (0.1%) View
Receptor_2B4 (PF11465) 108 (0.1%) View
Ig_5 (PF16681) 76 (0.0%) View
SVA (PF05326) 74 (0.0%) View
UL141 (PF16758) 70 (0.0%) View
Ig_Tie2_1 (PF10430) 67 (0.0%) View
Izumo-Ig (PF16706) 51 (0.0%) View
Adhes-Ig_like (PF09085) 50 (0.0%) View
PTCRA (PF15028) 34 (0.0%) View
Total: 28 Total: 180676 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 229 interactions for this clan. More...

Interacting families
A B
A2M A2M
A2M_N
A2M_N_2
A2M_recep
CompInhib_SCIN
NTR
SSL_OB
Stap_Strp_tox_C
Sushi
Trypsin
V-set
A2M_N A2M
A2M_N_2 A2M
V-set
A2M_recep A2M
Adeno_knob V-set
AMA-1 V-set
Arena_glycoprot C1-set
Arm Ig_3
Asp V-set
Bet_v_1 C1-set
Beta-APP V-set
C1-set Adeno_GP19K
B
C1-set
Cytomega_US3
DUF1968
Hemagglutinin
Herpes_gE
ig
Ig_2
Ig_3
IgG_binding_B
Lectin_C
MA-Mit
MHC_I
MHC_II_alpha
MHC_II_beta
Pox_T4_C
Pox_T4_N
PRY
SPRY
SSL_OB
Stap_Strp_tox_C
Stap_Strp_toxin
SVA
V-set
C2-set C2-set
CD4-extracel
I-set
C2-set_2 C2-set_2
ig
Ig_2
V-set
Carb_anhydrase I-set
Ig_2
CD4-extracel C2-set
CompInhib_SCIN A2M
COX2 V-set
COX2_TM V-set
CSF-1 I-set
Ig_2
Cytomega_US3 C1-set
DHFR_1 V-set
DsbB V-set
DUF1949 V-set
DUF1968 C1-set
Duffy_binding V-set
FGF I-set
Flavi_glycop_C V-set
Flavi_glycoprot V-set
Flt3_lig ig
fn3 I-set
V-set
Furin-like V-set
G2F Ig_2
Glyco_hydro_6 V-set
GP120 ig
V-set
GP41 V-set
Hemagglutinin C1-set
V-set
Herpes_gE Herpes_gE
Herpes_glycop_D Herpes_glycop_D
V-set
HN V-set
I-set C2-set
FGF
fn3
I-set
Ig_2
Ig_3
LRR_8
LRRNT
Telethonin
V-set
ICAM_N ICAM_N
Ig_2
VWA
ig C2-set
fn3
ig
Ig_2
Ig_3
MHC_I
SCF
V-set
Ig_2 C1-set
C2-set_2
fn3
I-set
ICAM_N
ig
Ig_2
Ig_3
S_100
SCF
Serum_albumin
SSL_OB
TNFR_c6
V-set
Ig_3 I-set
ig
Ig_2
Ig_3
Ig_Tie2_1 Ig_2
IL1 ig
Ig_2
Ig_3
V-set
IL34 I-set
ig
Ig_2
Interferon Ig_2
Ig_3
Laminin_G_1 Ig_2
V-set
Lectin_C C1-set
Lep_receptor_Ig IL6Ra-bind
Leukocidin V-set
Lipoprot_C V-set
LRR_1 I-set
LRR_8 I-set
Lys V-set
MA-Mit V-set
MAM ig
MHC_I C1-set
ig
Ig_2
Ig_3
SVA
V-set
MHC_II_alpha C1-set
V-set
MHC_II_beta C1-set
V-set
Neur V-set
NGF I-set
PDGF Ig_2
V-set
Pentaxin Ig_2
Peptidase_M16_C V-set
Peptidase_S9 V-set
Pkinase I-set
Prion V-set
PSI Ig_2
PTCRA PTCRA
Receptor_2B4 Receptor_2B4
Reo_sigma1 V-set
Rhv ICAM_N
Rieske V-set
RnaseA V-set
SBP_bac_1 C2-set_2
I-set
SCF I-set
Ig_2
Sema ig
Ig_2
Stap_Strp_tox_C C1-set
V-set
Stap_Strp_toxin C1-set
V-set
Sushi A2M
Telethonin I-set
TNF V-set
V-set Adeno_knob
B
B1
Beta-APP
C1-set
C2-set
C2-set_2
CD4-extracel
Collagen
Corona_S1
DUF1968
Furin-like
Fusion_gly
Gag_p24
GP120
Hemagglutinin
HRM
ig
Ig_2
Ig_3
IL8
Lys
MazE_antitoxin
Mesothelin
MHC_I
MHC_II_alpha
MHC_II_beta
Recep_L_domain
Receptor_2B4
Rhv
RRF
Stap_Strp_tox_C
Stap_Strp_toxin
TNF
ubiquitin
UPAR_LY6
V-set
V-set_CD47
vMSA
V-set_CD47 V-set
V-set_CD47
Voltage_CLC V-set
VWA ICAM_N
V-set

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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