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231  structures 20252  species 26  interactions 124033  sequences 647  architectures

Clan: KH (CL0007)

Summary

K-Homology (KH) domain Superfamily Add an annotation

The KH domain is thought to be the second most prevalent RNA binding motif in proteins. The motif is characterised by a conserved GXXXGXXG in the middle of the domain. Structures of KH reveal that the KH domain is arranged as either a beta-alpha-alpha-beta-beta (mini-KH domain) or beta-alpha-alpha-beta-beta-alpha (maxi-KH domain). The secondary elements are separated by at least four loop segments. The second loop is located between beta-1 and al The KH domain can be found either as single or multiple copies. The KH domain usually binds RNA as a multimer.

This clan contains 7 families and the total number of domains in the clan is 124033. The clan was built by RD Finn.

Members

This clan contains the following 7 member families:

KH_1 KH_2 KH_3 KH_4 KH_5 KH_6 MOEP19

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
KH_1 (PF00013) 52032 (42.0%) View
KH_2 (PF07650) 39576 (31.9%) View
KH_5 (PF13184) 19141 (15.4%) View
KH_4 (PF13083) 11070 (8.9%) View
KH_6 (PF15985) 1078 (0.9%) View
KH_3 (PF13014) 959 (0.8%) View
MOEP19 (PF16005) 177 (0.1%) View
Total: 7 Total: 124033 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 26 interactions for this clan. More...

Interacting families
A B
EIF_2_alpha KH_1
KH_1 KH_1
RNase_PH
RNase_PH_C
S1
KH_2 Beta-Casp
KH_2
Lactamase_B
Ribosomal_S10
Ribosomal_S14
Ribosomal_S17e
Ribosomal_S3_C
Ribosomal_S7e
S10_plectin
KH_4 KH_4
R3H
MMR_HSR1 KH_2
R3H KH_4
Ribosomal_S10 KH_2
Ribosomal_S11 KH_2
Ribosomal_S14 KH_2
Ribosomal_S4e KH_2
RNase_PH KH_1
RNase_PH_C KH_1
S1 KH_1
S10_plectin KH_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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