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46  structures 6902  species 10  interactions 26971  sequences 370  architectures

Clan: KNTase_C (CL0291)


Nucleotidyltransferase substrate binding domain Add an annotation

This alpha helical domain is found associated with a variety of nucleotidyltransferase domains.

This clan contains 25 families and the total number of domains in the clan is 26971. The clan was built by A Bateman.


This clan contains the following 25 member families:

AadA_C DUF294_C DUF4145 DUF86 GlnD_UR_UTase HEPN HEPN-like_int HEPN_AbiA_CTD HEPN_AbiU2 HEPN_AbiV HEPN_Apea HEPN_Cthe2314 HEPN_DZIP3 HEPN_LA2681 HEPN_MAE_28990 HEPN_RiboL-PSP HEPN_RnaseLS HEPN_SAV2148 HEPN_SAV_6107 HEPN_STY4199 HEPN_Swt1 KNTase_C NTase_sub_bind PaREP1 pEK499_p136

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GlnD_UR_UTase (PF08335) 10153 (37.6%) View
DUF86 (PF01934) 4068 (15.1%) View
HEPN (PF05168) 3666 (13.6%) View
DUF294_C (PF10335) 2531 (9.4%) View
DUF4145 (PF13643) 1454 (5.4%) View
NTase_sub_bind (PF08780) 1000 (3.7%) View
HEPN_SAV_6107 (PF18726) 655 (2.4%) View
HEPN_Apea (PF18739) 541 (2.0%) View
HEPN_RiboL-PSP (PF18735) 434 (1.6%) View
HEPN_Swt1 (PF18731) 425 (1.6%) View
HEPN_DZIP3 (PF18738) 374 (1.4%) View
PaREP1 (PF05942) 359 (1.3%) View
HEPN_SAV2148 (PF18725) 237 (0.9%) View
Pfam family Num. domains Alignment
HEPN_AbiU2 (PF18734) 218 (0.8%) View
HEPN_Cthe2314 (PF18730) 166 (0.6%) View
HEPN_AbiV (PF18728) 164 (0.6%) View
HEPN_MAE_28990 (PF18737) 148 (0.5%) View
HEPN_RnaseLS (PF18869) 113 (0.4%) View
HEPN_LA2681 (PF18733) 99 (0.4%) View
KNTase_C (PF07827) 67 (0.2%) View
HEPN_STY4199 (PF18729) 35 (0.1%) View
pEK499_p136 (PF18736) 33 (0.1%) View
AadA_C (PF18280) 21 (0.1%) View
HEPN_AbiA_CTD (PF18732) 7 (0.0%) View
HEPN-like_int (PF18867) 3 (0.0%) View
Total: 25 Total: 26971 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
GlnD_UR_UTase GlnD_UR_UTase
GlnE GlnD_UR_UTase
KNTase_C KNTase_C
NTase_sub_bind NTase_sub_bind
NTP_transf_2 KNTase_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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