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113  structures 676  species 14  interactions 15258  sequences 618  architectures

Clan: Kazal (CL0005)


Kazal like domain Add an annotation

Kazal domains are found in both serine protease inhibitors and extracellular regions of agrins. The structure of the Kazal domain is a small alpha/beta fold. Typically the Kazal domain consists of 2 short-helices and a 3-stranded anti-parallel sheet. The fold is contains several disulphide bonds.

This clan contains 3 families and the total number of domains in the clan is 15258. The clan was built by RD Finn.

Literature references

  1. Laskowski M Jr, Kato I; , Annu Rev Biochem 1980;49:593-626.: Protein inhibitors of proteinases. PUBMED:6996568 EPMC:6996568


This clan contains the following 3 member families:

Kazal_1 Kazal_2 Kazal_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Kazal_2 (PF07648) 10945 (71.7%) View
Kazal_1 (PF00050) 4170 (27.3%) View
Kazal_3 (PF18434) 143 (0.9%) View
Total: 3 Total: 15258 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
FOLN Kazal_1
IGFBP Kazal_2
Kazal_1 Collagen
Kazal_2 Kazal_2
Peptidase_S8 Kazal_1
TGF_beta Kazal_1
Trypsin Kazal_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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