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10  structures 1605  species 3  interactions 1955  sequences 13  architectures

Clan: Kleisin (CL0157)

Summary

Kleisin superfamily Add an annotation

The kleisin superfamily includes ScpA, Scc1, Rec8, and Barren [1]. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure [1].

This clan contains 2 families and the total number of domains in the clan is 1955. The clan was built by A Bateman.

Literature references

  1. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F; , Mol Cell 2003;11:571-575.: Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. PUBMED:12667442 EPMC:12667442

Members

This clan contains the following 2 member families:

Rad21_Rec8 SMC_ScpA

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SMC_ScpA (PF02616) 1263 (64.6%) View
Rad21_Rec8 (PF04824) 692 (35.4%) View
Total: 2 Total: 1955 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
SMC_N Rad21_Rec8
SMC_ScpA
SMC_ScpA SMC_ScpB

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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