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175  structures 220  species 3  interactions 2209  sequences 25  architectures

Clan: Knottin_1 (CL0054)


Scorpion toxin-like knottin superfamily Add an annotation

This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.

This clan contains 15 families and the total number of domains in the clan is 2209. The clan was built by A Bateman.


This clan contains the following 15 member families:

BmKX Defensin_2 Defensin_5 Defensin_like Gamma-thionin Macin SCRL SLR1-BP Toxin_17 Toxin_2 Toxin_3 Toxin_37 Toxin_38 Toxin_5 Toxin_6

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Gamma-thionin (PF00304) 1055 (47.8%) View
SLR1-BP (PF07333) 440 (19.9%) View
Defensin_2 (PF01097) 231 (10.5%) View
Defensin_like (PF10868) 183 (8.3%) View
SCRL (PF06876) 164 (7.4%) View
Toxin_3 (PF00537) 84 (3.8%) View
Macin (PF14865) 32 (1.4%) View
BmKX (PF09132) 16 (0.7%) View
Defensin_5 (PF18251) 4 (0.2%) View
Toxin_38 (PF14866) 0 (0.0%) View
Toxin_37 (PF11415) 0 (0.0%) View
Toxin_17 (PF08086) 0 (0.0%) View
Toxin_6 (PF05453) 0 (0.0%) View
Toxin_5 (PF05294) 0 (0.0%) View
Toxin_2 (PF00451) 0 (0.0%) View
Total: 15 Total: 2209 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Gamma-thionin Gamma-thionin
Toxin_2 Toxin_2
Toxin_3 Toxin_3


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...