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70  structures 584  species 6  interactions 3843  sequences 51  architectures

Clan: LIG (CL0532)


Lipid-binding Ig-like superfamily Add an annotation

This superfamily includes a number of lipid binding families that have a similar topology to the immunoglobulin fold. The family includes The ML domain Pfam:PF02221. It includes the uncharacterised family Pfam:PF06477.

This clan contains 3 families and the total number of domains in the clan is 3843. The clan was built by A Bateman.

Literature references

  1. Johannessen BR, Skov LK, Kastrup JS, Kristensen O, Bolwig C, Larsen JN, Spangfort M, Lund K, Gajhede M;, FEBS Lett. 2005;579:1208-1212.: Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity. PUBMED:15710415 EPMC:15710415
  2. Wright CS, Mi LZ, Lee S, Rastinejad F;, Biochemistry. 2005;44:13510-13521.: Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity. PUBMED:16216074 EPMC:16216074


This clan contains the following 3 member families:

DUF1091 E1_DerP2_DerF2 TRP_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
E1_DerP2_DerF2 (PF02221) 1740 (45.3%) View
DUF1091 (PF06477) 1230 (32.0%) View
TRP_N (PF14558) 873 (22.7%) View
Total: 3 Total: 3843 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
DUF3439 E1_DerP2_DerF2
E1_DerP2_DerF2 DUF3439
LRR_1 E1_DerP2_DerF2
LRR_4 E1_DerP2_DerF2
LRR_8 E1_DerP2_DerF2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...