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710  structures 3962  species 72  interactions 358399  sequences 11344  architectures

Clan: LRR (CL0022)


Leucine Rich Repeat Add an annotation

Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. This Pfam entry contains Leucine Rich Repeats not recognised by the Pfam:PF00560 model.

This clan contains 12 families and the total number of domains in the clan is 358399. The clan was built by DJ Studholme.

Literature references

  1. Kobe B, Deisenhofer J; , Trends Biochem Sci 1994;19:415-421.: The leucine-rich repeat: a versatile binding motif. PUBMED:7817399 EPMC:7817399
  2. Kobe B, Deisenhofer J; , Nature 1993;366:751-756.: Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. PUBMED:8264799 EPMC:8264799


This clan contains the following 12 member families:

DUF285 FNIP LRR_1 LRR_2 LRR_3 LRR_4 LRR_5 LRR_6 LRR_8 LRR_9 Recep_L_domain TTSSLRR

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LRR_8 (PF13855) 200166 (55.9%) View
LRR_6 (PF13516) 74633 (20.8%) View
LRR_5 (PF13306) 22753 (6.3%) View
LRR_1 (PF00560) 22406 (6.3%) View
LRR_4 (PF12799) 10028 (2.8%) View
LRR_9 (PF14580) 7623 (2.1%) View
DUF285 (PF03382) 6472 (1.8%) View
FNIP (PF05725) 6432 (1.8%) View
Recep_L_domain (PF01030) 4669 (1.3%) View
LRR_2 (PF07723) 1723 (0.5%) View
LRR_3 (PF07725) 1451 (0.4%) View
TTSSLRR (PF12468) 43 (0.0%) View
Total: 12 Total: 358399 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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