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162  structures 212  species 7  interactions 757  sequences 8  architectures

Clan: Leukocidin (CL0636)


Leukocidin-like superfamily Add an annotation

According to SCOP this superfamily contains beta-sandwich of Ig-like (greek-key) topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel.

This clan contains 3 families and the total number of domains in the clan is 757. The clan was built by A Bateman.


This clan contains the following 3 member families:

Hemolysin_N Leukocidin MspA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MspA (PF09203) 648 (85.6%) View
Leukocidin (PF07968) 95 (12.5%) View
Hemolysin_N (PF12563) 14 (1.8%) View
Total: 3 Total: 757 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
Hemolysin_N Leukocidin
Leukocidin Hemolysin_N
MspA MspA


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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