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1873  structures 20230  species 34  interactions 161636  sequences 721  architectures

Clan: Lysozyme (CL0037)

Summary

Lysozyme-like superfamily Add an annotation

Barley chitinase, bacterial chitosanase, and lysozymes from phage and animals all hydrolyse related polysaccharides. The proteins little amino-acid similarity, but have a structurally invariant core consisting of two helices and a three-stranded beta-sheet which form the substrate-binding and catalytic cleft [1].

This clan contains 12 families and the total number of domains in the clan is 161636. The clan was built by A Bateman.

Literature references

  1. Monzingo AF, Marcotte EM, Hart PJ, Robertus JD; , Nat Struct Biol 1996;3:133-140.: Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core. PUBMED:8564539 EPMC:8564539

Members

This clan contains the following 12 member families:

Glucosaminidase Glyco_hydro_108 Glyco_hydro_19 Glyco_hydro_46 Glyco_hydro_80 Lys Lysozyme_like Phage_lysozyme SLT SLT_2 TraH_2 Transglycosylas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SLT (PF01464) 58946 (36.5%) View
Glucosaminidase (PF01832) 42484 (26.3%) View
SLT_2 (PF13406) 14559 (9.0%) View
Phage_lysozyme (PF00959) 14423 (8.9%) View
Transglycosylas (PF06737) 13968 (8.6%) View
Glyco_hydro_19 (PF00182) 5589 (3.5%) View
Glyco_hydro_108 (PF05838) 4992 (3.1%) View
Lysozyme_like (PF13702) 4930 (3.1%) View
Lys (PF00062) 1369 (0.8%) View
Glyco_hydro_46 (PF01374) 297 (0.2%) View
TraH_2 (PF06871) 64 (0.0%) View
Glyco_hydro_80 (PF13647) 15 (0.0%) View
Total: 12 Total: 161636 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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