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1502  structures 5612  species 11  interactions 33680  sequences 527  architectures

Clan: Lysozyme (CL0037)


Lysozyme-like superfamily Add an annotation

Barley chitinase, bacterial chitosanase, and lysozymes from phage and animals all hydrolyse related polysaccharides. The proteins little amino-acid similarity, but have a structurally invariant core consisting of two helices and a three-stranded beta-sheet which form the substrate-binding and catalytic cleft [1].

This clan contains 12 families and the total number of domains in the clan is 33680. The clan was built by A Bateman.

Literature references

  1. Monzingo AF, Marcotte EM, Hart PJ, Robertus JD; , Nat Struct Biol 1996;3:133-140.: Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core. PUBMED:8564539 EPMC:8564539


This clan contains the following 12 member families:

Glucosaminidase Glyco_hydro_108 Glyco_hydro_19 Glyco_hydro_46 Lys Lysozyme_like Phage_lysozyme REGB_T4 SLT SLT_2 TraH_2 Transglycosylas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SLT (PF01464) 14235 (42.3%) View
Glucosaminidase (PF01832) 6435 (19.1%) View
Phage_lysozyme (PF00959) 3255 (9.7%) View
SLT_2 (PF13406) 3080 (9.1%) View
Glyco_hydro_19 (PF00182) 2104 (6.2%) View
Transglycosylas (PF06737) 1273 (3.8%) View
Lysozyme_like (PF13702) 1147 (3.4%) View
Lys (PF00062) 1035 (3.1%) View
Glyco_hydro_108 (PF05838) 820 (2.4%) View
REGB_T4 (PF10715) 136 (0.4%) View
Glyco_hydro_46 (PF01374) 127 (0.4%) View
TraH_2 (PF06871) 33 (0.1%) View
Total: 12 Total: 33680 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
Lys Lys
Glyco_hydro_108 Glyco_hydro_108
Glyco_hydro_19 Glyco_hydro_19
Glyco_hydro_46 Glyco_hydro_46
Phage_lysozyme Phage_lysozyme


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...