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448  structures 11470  species 37  interactions 445171  sequences 772  architectures

Clan: MBB (CL0193)


Outer membrane beta-barrel protein superfamily Add an annotation

This clan gathers together a large set of beta barrel membrane proteins.Although these proteins have different numbers of beta strands in the barrel they have significant sequence similarity between families.

This clan contains 59 families and the total number of domains in the clan is 445171. The clan was built by A Bateman.


This clan contains the following 59 member families:

Ail_Lom Autotransporter Bac_surface_Ag BBP2 BBP2_2 Campylo_MOMP Channel_Tsx CopB DUF2490 DUF2860 DUF3078 DUF3138 DUF3187 DUF3308 DUF3575 DUF481 DUF560 Gcw_chp HP_OMP HP_OMP_2 KdgM LamB Legionella_OMP MipA MtrB_PioB Omp_AT OMP_b-brl OMP_b-brl_2 OMP_b-brl_3 OmpA_like OmpA_membrane Omptin OmpW Opacity OpcA OprB OprD OprF OstA_C PagL PagP Phenol_MetA_deg Porin_1 Porin_10 Porin_2 Porin_4 Porin_7 Porin_8 Porin_O_P Porin_OmpG ShlB Surface_Ag_2 TcfC Toluene_X TonB_dep_Rec TraF_2 TSA Usher YfaZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TonB_dep_Rec (PF00593) 108668 (24.4%) View
Usher (PF00577) 41524 (9.3%) View
Autotransporter (PF03797) 37161 (8.3%) View
Porin_1 (PF00267) 23675 (5.3%) View
OMP_b-brl (PF13505) 21739 (4.9%) View
Bac_surface_Ag (PF01103) 20912 (4.7%) View
OprD (PF03573) 15007 (3.4%) View
Toluene_X (PF03349) 11197 (2.5%) View
HP_OMP (PF01856) 10754 (2.4%) View
Porin_4 (PF13609) 10093 (2.3%) View
LamB (PF02264) 8916 (2.0%) View
Channel_Tsx (PF03502) 8519 (1.9%) View
OmpW (PF03922) 8500 (1.9%) View
OstA_C (PF04453) 7124 (1.6%) View
KdgM (PF06178) 6676 (1.5%) View
MipA (PF06629) 6654 (1.5%) View
Ail_Lom (PF06316) 6487 (1.5%) View
Surface_Ag_2 (PF01617) 5568 (1.3%) View
Phenol_MetA_deg (PF13557) 5532 (1.2%) View
OMP_b-brl_3 (PF14905) 5313 (1.2%) View
DUF481 (PF04338) 5023 (1.1%) View
OprB (PF04966) 4843 (1.1%) View
OmpA_membrane (PF01389) 4656 (1.0%) View
ShlB (PF03865) 4552 (1.0%) View
OMP_b-brl_2 (PF13568) 4242 (1.0%) View
YfaZ (PF07437) 3970 (0.9%) View
TcfC (PF16967) 3502 (0.8%) View
Porin_O_P (PF07396) 3485 (0.8%) View
PagP (PF07017) 3455 (0.8%) View
Gcw_chp (PF09694) 2984 (0.7%) View
Pfam family Num. domains Alignment
Omptin (PF01278) 2919 (0.7%) View
CopB (PF05275) 2733 (0.6%) View
DUF3575 (PF12099) 2346 (0.5%) View
Porin_8 (PF16966) 2340 (0.5%) View
HP_OMP_2 (PF02521) 2253 (0.5%) View
PagL (PF09411) 2237 (0.5%) View
Porin_2 (PF02530) 2174 (0.5%) View
DUF560 (PF04575) 2145 (0.5%) View
TraF_2 (PF13729) 2129 (0.5%) View
Porin_OmpG (PF09381) 1755 (0.4%) View
Opacity (PF02462) 1373 (0.3%) View
BBP2_2 (PF10082) 1282 (0.3%) View
DUF3308 (PF11751) 1114 (0.3%) View
BBP2 (PF07642) 880 (0.2%) View
DUF3078 (PF11276) 742 (0.2%) View
Campylo_MOMP (PF05538) 659 (0.1%) View
OprF (PF05736) 615 (0.1%) View
TSA (PF03249) 593 (0.1%) View
DUF2490 (PF10677) 545 (0.1%) View
Porin_10 (PF14121) 538 (0.1%) View
DUF2860 (PF11059) 537 (0.1%) View
Porin_7 (PF16956) 452 (0.1%) View
Legionella_OMP (PF05150) 439 (0.1%) View
OmpA_like (PF16961) 431 (0.1%) View
OpcA (PF07239) 314 (0.1%) View
DUF3187 (PF11383) 303 (0.1%) View
Omp_AT (PF11557) 277 (0.1%) View
MtrB_PioB (PF11854) 210 (0.0%) View
DUF3138 (PF11336) 105 (0.0%) View
Total: 59 Total: 445171 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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