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32  structures 844  species 4  interactions 13855  sequences 264  architectures

Clan: MBD-like (CL0081)


MBD-like DNA-binding domain Add an annotation

This clan contains proteins with a distinctive three stranded DNA-binding domain [1].

This clan contains 7 families and the total number of domains in the clan is 13855. The clan was built by A Bateman.

Literature references

  1. Connolly KM, Ilangovan U, Wojciak JM, Iwahara M, Clubb RT; , J Mol Biol 2000;300:841-856.: Major groove recognition by three-stranded beta-sheets: affinity determinants and conserved structural features. PUBMED:10891272 EPMC:10891272


This clan contains the following 7 member families:

AP2 DUF3596 Integrase_AP2 Integrase_DNA MBD MBDa Phage_integ_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AP2 (PF00847) 10834 (78.2%) View
MBD (PF01429) 1824 (13.2%) View
Integrase_AP2 (PF14657) 499 (3.6%) View
MBDa (PF16564) 283 (2.0%) View
DUF3596 (PF12167) 184 (1.3%) View
Integrase_DNA (PF02920) 174 (1.3%) View
Phage_integ_N (PF09003) 57 (0.4%) View
Total: 7 Total: 13855 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
Phage_int_SAM_1 Phage_integ_N
Phage_integ_N Phage_int_SAM_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...