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293  structures 591  species 9  interactions 4461  sequences 191  architectures

Clan: Man_lectin (CL0568)


Mannoase-binding lectin superfamily Add an annotation

This familu of lectins has a beta-prism fold [1-2].

This clan contains 5 families and the total number of domains in the clan is 4461. The clan was built by RY Eberhardt.

Literature references

  1. Jeyaprakash AA, Geetha Rani P, Banuprakash Reddy G, Banumathi S, Betzel C, Sekar K, Surolia A, Vijayan M;, J Mol Biol. 2002;321:637-645.: Crystal structure of the jacalin-T-antigen complex and a comparative study of lectin-T-antigen complexes. PUBMED:12206779 EPMC:12206779
  2. Levan S, De S, Olson R;, J Mol Biol. 2013;425:944-957.: Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity. PUBMED:23274141 EPMC:23274141


This clan contains the following 5 member families:

Beta-prism_lec Endotoxin_M Endotoxin_mid Jacalin VOMI

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Jacalin (PF01419) 4054 (90.9%) View
VOMI (PF03762) 381 (8.5%) View
Beta-prism_lec (PF16458) 20 (0.4%) View
Endotoxin_mid (PF09131) 4 (0.1%) View
Endotoxin_M (PF00555) 2 (0.0%) View
Total: 5 Total: 4461 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 9 interactions for this clan. More...

Interacting families
Endotoxin_C Endotoxin_M
Endotoxin_M Endotoxin_C
Endotoxin_mid Endotoxin_C
Endotoxin_N Endotoxin_M
Jacalin Jacalin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...