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28  structures 3097  species 0  interactions 26408  sequences 273  architectures

Clan: MtN3-like (CL0141)


MtN3-like, vesicle-trafficking cargo-receptors Add an annotation

The clan forms a large and diverse family of proteins with seven transmembrane helices, common topology and, most likely, similar function. Their coding genes exist in all eukaryota and in several prokaryota. Some are responsible for metabolic diseases (cystinosis, congenital disorder of glycosylation), others are candidate genes for genetic disorders (cleft lip and palate, certain forms of cancer) or solute uptake and efflux (SWEETs) and many have not yet been assigned a function. Comparison with the properties of well-annotated clan members suggests that the proteins could be involved in protein trafficking and serve as cargo receptors in vesicle trafficking [3].

This clan contains 5 families and the total number of domains in the clan is 26408. The clan was built by J Mistry.

Literature references

  1. Gamas P, Niebel Fd, Lescure N, Cullimore J; , Mol Plant Microbe Interact 1996;9:233-242.: Use of a subtractive hybridization approach to identify new Medicago truncatula genes induced during root nodule development. PUBMED:8634476 EPMC:8634476
  2. Tagoh H, Kishi H, Muraguchi A; , Biochem Biophys Res Commun 1996;221:744-749.: Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors. PUBMED:8630032 EPMC:8630032
  3. Saudek V;, PLoS One. 2012;7:e30876.: Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking. PUBMED:22363504 EPMC:22363504


This clan contains the following 5 member families:

ER_lumen_recept LAB_N MPC MtN3_slv PQ-loop

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PQ-loop (PF04193) 12949 (49.0%) View
MtN3_slv (PF03083) 7387 (28.0%) View
MPC (PF03650) 2583 (9.8%) View
ER_lumen_recept (PF00810) 2580 (9.8%) View
LAB_N (PF07578) 909 (3.4%) View
Total: 5 Total: 26408 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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