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11351  structures 37193  species 392  interactions 3791318  sequences 12618  architectures

Clan: NADP_Rossmann (CL0063)

Summary

FAD/NAD(P)-binding Rossmann fold Superfamily Add an annotation

A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme. The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction. Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site [1]. In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD.

This clan contains 181 families and the total number of domains in the clan is 3791318. The clan was built by RD Finn.

Literature references

  1. Bashton M, Chothia C; , J Mol Biol 2002;315:927-939.: The geometry of domain combination in proteins. PUBMED:11812158 EPMC:11812158

Members

This clan contains the following 181 member families:

2-Hacid_dh_C 3Beta_HSD 3HCDH_N adh_short adh_short_C2 ADH_zinc_N ADH_zinc_N_2 AdoHcyase_NAD AdoMet_MTase AlaDh_PNT_C Amino_oxidase ApbA AviRa B12-binding Bac_GDH Bin3 CheR CMAS CmcI CoA_binding CoA_binding_2 CoA_binding_3 Cons_hypoth95 DAO DapB_N DFP DNA_methylase DOT1 DREV DUF1442 DUF166 DUF1776 DUF2431 DUF268 DUF3321 DUF364 DUF43 DUF938 DXP_redisom_C DXP_reductoisom Eco57I ELFV_dehydrog Eno-Rase_FAD_bd Eno-Rase_NADH_b Enoyl_reductase Epimerase F420_oxidored FAD_binding_2 FAD_binding_3 FAD_oxidored Fibrillarin FMO-like FmrO FtsJ G6PD_N GCD14 GDI GDP_Man_Dehyd GFO_IDH_MocA GIDA GidB GLF Glu_dehyd_C Glyco_hydro_4 GMC_oxred_N Gp_dh_N GRAS GRDA HI0933_like HIM1 IlvN K_oxygenase KR LCM Ldh_1_N Lycopene_cycl Malic_M Mannitol_dh MCRA Met_10 Methyltrans_Mon Methyltrans_SAM Methyltransf_10 Methyltransf_11 Methyltransf_12 Methyltransf_15 Methyltransf_16 Methyltransf_17 Methyltransf_18 Methyltransf_19 Methyltransf_2 Methyltransf_20 Methyltransf_21 Methyltransf_22 Methyltransf_23 Methyltransf_24 Methyltransf_25 Methyltransf_26 Methyltransf_28 Methyltransf_29 Methyltransf_3 Methyltransf_30 Methyltransf_31 Methyltransf_32 Methyltransf_34 Methyltransf_4 Methyltransf_5 Methyltransf_7 Methyltransf_8 Methyltransf_9 Methyltransf_PK MethyltransfD12 MetW Mg-por_mtran_C Mqo MT-A70 MTS Mur_ligase N2227 N6-adenineMlase N6_Mtase N6_N4_Mtase NAD_binding_10 NAD_binding_2 NAD_binding_3 NAD_binding_4 NAD_binding_5 NAD_binding_7 NAD_binding_8 NAD_binding_9 NAD_Gly3P_dh_N NAS NmrA NNMT_PNMT_TEMT NodS Nol1_Nop2_Fmu NSP13 OCD_Mu_crystall PARP_regulatory PCMT PDH Polysacc_synt_2 Pox_MCEL Prenylcys_lyase PrmA PRMT5 Pyr_redox Pyr_redox_2 Pyr_redox_3 RmlD_sub_bind Rossmann-like rRNA_methylase RrnaAD Rsm22 RsmJ Sacchrp_dh_NADP SAM_MT SAMBD SE Semialdhyde_dh Shikimate_DH Spermine_synth TehB THF_DHG_CYH_C Thi4 ThiF TPMT TrkA_N TRM TRM13 TrmK tRNA_U5-meth_tr Trp_halogenase TylF Ubie_methyltran UDPG_MGDP_dh_N UPF0020 UPF0146 V_cholerae_RfbT XdhC_C YjeF_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
adh_short (PF00106) 406662 (10.7%) View
Pyr_redox_2 (PF07992) 264575 (7.0%) View
ADH_zinc_N (PF00107) 195604 (5.2%) View
Epimerase (PF01370) 127456 (3.4%) View
Methyltransf_11 (PF08241) 107758 (2.8%) View
2-Hacid_dh_C (PF02826) 96268 (2.5%) View
DAO (PF01266) 93985 (2.5%) View
FAD_binding_3 (PF01494) 72742 (1.9%) View
GFO_IDH_MocA (PF01408) 72361 (1.9%) View
FAD_binding_2 (PF00890) 63581 (1.7%) View
TrkA_N (PF02254) 61122 (1.6%) View
Mur_ligase (PF01225) 58018 (1.5%) View
Methyltransf_31 (PF13847) 54417 (1.4%) View
NAD_binding_2 (PF03446) 53112 (1.4%) View
GDP_Man_Dehyd (PF16363) 51455 (1.4%) View
ThiF (PF00899) 48923 (1.3%) View
Semialdhyde_dh (PF01118) 46251 (1.2%) View
Gp_dh_N (PF00044) 43914 (1.2%) View
Amino_oxidase (PF01593) 42853 (1.1%) View
MTS (PF05175) 42773 (1.1%) View
Methyltransf_23 (PF13489) 38109 (1.0%) View
3HCDH_N (PF02737) 37336 (1.0%) View
LCM (PF04072) 36272 (1.0%) View
N6_Mtase (PF02384) 35893 (0.9%) View
Ldh_1_N (PF00056) 35405 (0.9%) View
KR (PF08659) 35107 (0.9%) View
CoA_binding (PF02629) 31859 (0.8%) View
GMC_oxred_N (PF00732) 31174 (0.8%) View
tRNA_U5-meth_tr (PF05958) 30961 (0.8%) View
Pyr_redox_3 (PF13738) 30366 (0.8%) View
Shikimate_DH (PF01488) 29677 (0.8%) View
NAD_binding_10 (PF13460) 29303 (0.8%) View
Nol1_Nop2_Fmu (PF01189) 28792 (0.8%) View
CMAS (PF02353) 28607 (0.8%) View
Malic_M (PF03949) 28068 (0.7%) View
UDPG_MGDP_dh_N (PF03721) 27795 (0.7%) View
NAD_binding_8 (PF13450) 27673 (0.7%) View
Methyltransf_18 (PF12847) 27505 (0.7%) View
RrnaAD (PF00398) 27404 (0.7%) View
FtsJ (PF01728) 26377 (0.7%) View
B12-binding (PF02310) 26325 (0.7%) View
GIDA (PF01134) 26281 (0.7%) View
NAD_binding_3 (PF03447) 26030 (0.7%) View
F420_oxidored (PF03807) 25827 (0.7%) View
Mannitol_dh (PF01232) 25676 (0.7%) View
N6_N4_Mtase (PF01555) 25312 (0.7%) View
NmrA (PF05368) 25009 (0.7%) View
AlaDh_PNT_C (PF01262) 24880 (0.7%) View
ApbA (PF02558) 24779 (0.7%) View
DNA_methylase (PF00145) 23719 (0.6%) View
ELFV_dehydrog (PF00208) 23505 (0.6%) View
NAD_Gly3P_dh_N (PF01210) 23127 (0.6%) View
adh_short_C2 (PF13561) 22211 (0.6%) View
DapB_N (PF01113) 21801 (0.6%) View
THF_DHG_CYH_C (PF02882) 21427 (0.6%) View
ADH_zinc_N_2 (PF13602) 21255 (0.6%) View
DFP (PF04127) 20503 (0.5%) View
G6PD_N (PF00479) 20425 (0.5%) View
Methyltrans_SAM (PF10672) 20400 (0.5%) View
Methyltransf_4 (PF02390) 20227 (0.5%) View
Methyltransf_5 (PF01795) 19709 (0.5%) View
Methyltransf_3 (PF01596) 19439 (0.5%) View
Methyltransf_26 (PF13659) 19252 (0.5%) View
Cons_hypoth95 (PF03602) 19233 (0.5%) View
PrmA (PF06325) 19044 (0.5%) View
GidB (PF02527) 18764 (0.5%) View
Polysacc_synt_2 (PF02719) 18277 (0.5%) View
HI0933_like (PF03486) 18129 (0.5%) View
PDH (PF02153) 18117 (0.5%) View
IlvN (PF07991) 17591 (0.5%) View
Ubie_methyltran (PF01209) 17258 (0.5%) View
NAD_binding_4 (PF07993) 17167 (0.5%) View
Mqo (PF06039) 16156 (0.4%) View
UPF0020 (PF01170) 16009 (0.4%) View
CoA_binding_3 (PF13727) 15948 (0.4%) View
NAD_binding_7 (PF13241) 15644 (0.4%) View
CoA_binding_2 (PF13380) 15333 (0.4%) View
Glyco_hydro_4 (PF02056) 14078 (0.4%) View
MethyltransfD12 (PF02086) 13431 (0.4%) View
Methyltransf_12 (PF08242) 13184 (0.3%) View
RmlD_sub_bind (PF04321) 12900 (0.3%) View
Spermine_synth (PF01564) 12835 (0.3%) View
Sacchrp_dh_NADP (PF03435) 12580 (0.3%) View
YjeF_N (PF03853) 12350 (0.3%) View
DXP_reductoisom (PF02670) 12227 (0.3%) View
DXP_redisom_C (PF08436) 12173 (0.3%) View
NAD_binding_9 (PF13454) 11900 (0.3%) View
XdhC_C (PF13478) 11543 (0.3%) View
OCD_Mu_crystall (PF02423) 11354 (0.3%) View
CheR (PF01739) 11131 (0.3%) View
PCMT (PF01135) 10628 (0.3%) View
continued
Pfam family Num. domains Alignment
Methyltransf_21 (PF05050) 10140 (0.3%) View
3Beta_HSD (PF01073) 9255 (0.2%) View
Methyltransf_2 (PF00891) 9166 (0.2%) View
TrmK (PF04816) 8102 (0.2%) View
AdoHcyase_NAD (PF00670) 8037 (0.2%) View
FMO-like (PF00743) 7917 (0.2%) View
FAD_oxidored (PF12831) 7915 (0.2%) View
K_oxygenase (PF13434) 7733 (0.2%) View
rRNA_methylase (PF06962) 7466 (0.2%) View
MCRA (PF06100) 6952 (0.2%) View
RsmJ (PF04378) 6513 (0.2%) View
Methyltransf_30 (PF05430) 6481 (0.2%) View
SAM_MT (PF04445) 6080 (0.2%) View
Methyltransf_9 (PF08003) 5056 (0.1%) View
Methyltransf_10 (PF05971) 5046 (0.1%) View
Methyltransf_16 (PF10294) 5034 (0.1%) View
GLF (PF03275) 4903 (0.1%) View
TehB (PF03848) 4804 (0.1%) View
Bac_GDH (PF05088) 4596 (0.1%) View
Methyltransf_25 (PF13649) 4199 (0.1%) View
TPMT (PF05724) 3920 (0.1%) View
Methyltransf_28 (PF02636) 3774 (0.1%) View
GCD14 (PF08704) 3689 (0.1%) View
Methyltransf_32 (PF13679) 3609 (0.1%) View
Trp_halogenase (PF04820) 3391 (0.1%) View
Methyltransf_24 (PF13578) 3354 (0.1%) View
GRAS (PF03514) 3196 (0.1%) View
Rossmann-like (PF10727) 2957 (0.1%) View
MT-A70 (PF05063) 2858 (0.1%) View
MetW (PF07021) 2474 (0.1%) View
Methyltransf_20 (PF12147) 2361 (0.1%) View
Thi4 (PF01946) 2310 (0.1%) View
Eco57I (PF07669) 2176 (0.1%) View
GDI (PF00996) 2168 (0.1%) View
CmcI (PF04989) 2082 (0.1%) View
Met_10 (PF02475) 1953 (0.1%) View
Enoyl_reductase (PF12241) 1717 (0.0%) View
Eno-Rase_FAD_bd (PF07055) 1712 (0.0%) View
Eno-Rase_NADH_b (PF12242) 1705 (0.0%) View
TRM (PF02005) 1669 (0.0%) View
Methyltransf_29 (PF03141) 1596 (0.0%) View
Rsm22 (PF09243) 1487 (0.0%) View
Methyltransf_7 (PF03492) 1471 (0.0%) View
Methyltransf_19 (PF04672) 1467 (0.0%) View
NAD_binding_5 (PF07994) 1440 (0.0%) View
Lycopene_cycl (PF05834) 1346 (0.0%) View
NodS (PF05401) 1284 (0.0%) View
PRMT5 (PF05185) 1260 (0.0%) View
TylF (PF05711) 1207 (0.0%) View
Fibrillarin (PF01269) 1182 (0.0%) View
Pox_MCEL (PF03291) 1135 (0.0%) View
DOT1 (PF08123) 1111 (0.0%) View
DUF938 (PF06080) 907 (0.0%) View
N2227 (PF07942) 902 (0.0%) View
GRDA (PF04723) 877 (0.0%) View
Methyltransf_15 (PF09445) 825 (0.0%) View
DUF2431 (PF10354) 819 (0.0%) View
DUF364 (PF04016) 808 (0.0%) View
Methyltransf_PK (PF05891) 784 (0.0%) View
SE (PF08491) 778 (0.0%) View
NSP13 (PF06460) 725 (0.0%) View
Methyltransf_8 (PF05148) 717 (0.0%) View
Pyr_redox (PF00070) 717 (0.0%) View
NAS (PF03059) 678 (0.0%) View
N6-adenineMlase (PF10237) 617 (0.0%) View
Prenylcys_lyase (PF07156) 567 (0.0%) View
Glu_dehyd_C (PF16912) 558 (0.0%) View
Bin3 (PF06859) 542 (0.0%) View
TRM13 (PF05206) 519 (0.0%) View
AdoMet_MTase (PF07757) 457 (0.0%) View
Methyltransf_22 (PF13383) 438 (0.0%) View
NNMT_PNMT_TEMT (PF01234) 412 (0.0%) View
DUF3321 (PF11968) 409 (0.0%) View
Methyltrans_Mon (PF14314) 375 (0.0%) View
Mg-por_mtran_C (PF07109) 339 (0.0%) View
DREV (PF05219) 294 (0.0%) View
Methyltransf_34 (PF11312) 269 (0.0%) View
DUF43 (PF01861) 269 (0.0%) View
DUF1776 (PF08643) 266 (0.0%) View
DUF1442 (PF07279) 187 (0.0%) View
UPF0146 (PF03686) 187 (0.0%) View
PARP_regulatory (PF01358) 159 (0.0%) View
DUF268 (PF03269) 155 (0.0%) View
FmrO (PF07091) 152 (0.0%) View
Methyltransf_17 (PF12692) 142 (0.0%) View
DUF166 (PF02593) 134 (0.0%) View
V_cholerae_RfbT (PF05575) 120 (0.0%) View
HIM1 (PF08732) 81 (0.0%) View
SAMBD (PF16950) 42 (0.0%) View
AviRa (PF11599) 19 (0.0%) View
Total: 181 Total: 3791318 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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Interactions

There are 392 interactions for this clan. More...

Interacting families
A B
2-Hacid_dh 2-Hacid_dh_C
2-Hacid_dh_C 2-Hacid_dh
2-Hacid_dh_C
ATP-grasp
DUF3410
3HCDH 3HCDH_N
3HCDH_N 3HCDH
3HCDH_N
Thiolase_N
6PGD NAD_binding_2
ADH_N ADH_zinc_N
ADH_zinc_N_2
AlaDh_PNT_C
KR
adh_short adh_short
adh_short_C2 adh_short
adh_short_C2
ketoacyl-synt
Ketoacyl-synt_C
ADH_zinc_N ADH_N
ADH_zinc_N
PS-DH
ADH_zinc_N_2 ADH_N
ADH_zinc_N_2
AdoHcyase AdoHcyase_NAD
AdoHcyase_NAD AdoHcyase
AdoHcyase_NAD
AIF-MLS Pyr_redox_2
AIF_C Pyr_redox_2
AlaDh_PNT_C AlaDh_PNT_C
AlaDh_PNT_N
PNTB
AlaDh_PNT_N AlaDh_PNT_C
Amino_oxidase Amino_oxidase
Myb_DNA-binding
ApbA ApbA
ApbA_C
ApbA_C ApbA
ATP-grasp 2-Hacid_dh_C
ATP-grasp_2 CoA_binding
B12-binding B12-binding
Lys-AminoMut_A
Met_asp_mut_E
Met_synt_B12
MM_CoA_mutase
MtaB
B12-binding_2 B12-binding
BAH DNA_methylase
Biliv-reduc_cat GFO_IDH_MocA
Bin3 Bin3
CARM1 PRMT5
CheR_N CheR
Chromo DNA_methylase
CMAS CMAS
CmcI CmcI
CoA_binding ATP-grasp_2
CoA_binding
Ligase_CoA
Put_DNA-bind_N
Succ_CoA_lig
CoA_binding_2 Ank_2
CoA_binding_3 CoA_binding_3
Cons_hypoth95 Cons_hypoth95
CP12 Gp_dh_N
Cytochrom_C Pyr_redox_2
Cytochrom_c3_2 FAD_binding_2
DAO DAO
GCV_T
GCV_T_C
Methyltransf_30
SoxD
DapB_C DapB_N
DapB_N DapB_C
DapB_N
DFP DFP
DHO_dh NAD_binding_8
Dimerisation Methyltransf_2
DNA_methylase BAH
DNA_methylase
DNMT1-RFD DNA_methylase
DOT1 DOT1
DUF1971 TehB
DUF2520 F420_oxidored
Rossmann-like
DUF3410 2-Hacid_dh_C
DUF364 DUF364
DUF4213
DUF4213 DUF364
DXP_redisom_C DXP_redisom_C
DXP_reductoisom
DXPR_C
DXP_reductoisom DXP_redisom_C
DXPR_C
DXPR_C DXP_redisom_C
DXP_reductoisom
E2_bind ThiF
E3_binding Pyr_redox_2
ECH_1 3HCDH_N
ELFV_dehydrog ELFV_dehydrog
ELFV_dehydrog_N
ELFV_dehydrog_N ELFV_dehydrog
Eno-Rase_NADH_b Eno-Rase_FAD_bd
Enoyl_reductase
Enoyl_reductase Eno-Rase_FAD_bd
Epimerase Aldose_epim
DUF1731
Epimerase
Formyl_trans_C
Formyl_trans_N
F420_oxidored DUF1932
DUF2520
F420_oxidored
P5CR_dimer
FAD_binding_2 APS-reductase_C
Cytochrom_c3_2
FAD_binding_2
Fer2_3
Fer4
Fer4_17
Fer4_8
Fer4_9
Fumarate_red_C
Sdh_cyt
Succ_DH_flav_C
FAD_binding_3 FAD_binding_3
Phe_hydrox_dim
FAD_oxidored DAO
SoxD
SoxG
FDF YjeF_N
Fer2_4 DAO
FAD_oxidored
Pyr_redox_2
Fer4_20 NAD_binding_8
Pyr_redox
Pyr_redox_2
Fibrillarin Fibrillarin
Nop
Ribosomal_L7Ae
FMO-like FMO-like
Pyr_redox_3
Formyl_trans_C Epimerase
Formyl_trans_N Epimerase
FtsJ Flavi_NS5
FtsJ
G6PD_C G6PD_N
G6PD_N G6PD_C
G6PD_N
GCD14 GCD14
GCD14_N GCD14
GCV_T DAO
GCV_T_C DAO
GDI GDI
Ras
GFO_IDH_MocA Biliv-reduc_cat
GFO_IDH_MocA
GFO_IDH_MocA_C
GFO_IDH_MocA_C GFO_IDH_MocA
GIDA GIDA
GIDA_assoc
GIDA_assoc GIDA
GidB GidB
GLF GLF
NAD_binding_8
Glutaredoxin Pyr_redox_2
Glyco_hydro_4 Glyco_hydro_4
Glyco_hydro_4C
Glyco_hydro_4C Glyco_hydro_4
GMC_oxred_C GMC_oxred_N
GMC_oxred_N GMC_oxred_C
GMC_oxred_N
Gp_dh_C Gp_dh_N
Gp_dh_N CP12
Gp_dh_C
Gp_dh_N
HMGL-like Semialdhyde_dh
Homoserine_dh NAD_binding_3
HsdM_N N6_Mtase
IlvC IlvN
IlvN IlvC
IlvN
Inos-1-P_synth NAD_binding_5
K_oxygenase K_oxygenase
KR KR
LCM LCM
Metallophos
Ldh_1_C Ldh_1_N
Ldh_1_N Ldh_1_C
Ldh_1_N
Ligase_CoA CoA_binding
Lys-AminoMut_A B12-binding
malic Malic_M
Malic_M malic
Malic_M
Mannitol_dh Mannitol_dh_C
Met_10 Met_10
Methylase_S N6_Mtase
Methyltrans_SAM Methyltrans_SAM
PUA
UPF0020
Methyltransf_10 Methyltransf_10
Methyltransf_11 Methyltransf_11
Methyltransf_12 KR
Methyltransf_13 Methyltransf_23
Methyltransf_15 Methyltransf_15
Methyltransf_16 Methyltransf_16
Methyltransf_17 Methyltransf_17
Methyltransf_18 Methyltransf_18
Methyltransf_2 Dimerisation
Methyltransf_2
Methyltransf_23 Methyltransf_14
Methyltransf_23
Methyltransf_24 Methyltransf_24
Methyltransf_26 TaqI_C
Methyltransf_3 Methyltransf_3
Methyltransf_30 DAO
Methyltransf_30
Methyltransf_31 Methyltransf_31
RF-1
Methyltransf_4 Methyltransf_4
Methyltransf_7 Methyltransf_7
Methyltransf_8 Methyltransf_8
Methyltransf_PK Methyltransf_PK
MethyltransfD12 MethyltransfD12
MM_CoA_mutase B12-binding
MtaB B12-binding
MTS MTS
MTS_N MTS
Mur_ligase Mur_ligase
Mur_ligase_C
Mur_ligase_M
Mur_ligase_C Mur_ligase
Mur_ligase_M Mur_ligase
N6_Mtase HsdM_N
N6_Mtase
ocr
N6_N4_Mtase N6_N4_Mtase
NAD_binding_10 DUF1731
NAD_binding_10
NAD_binding_11 NAD_binding_2
NAD_binding_2 6PGD
ATP-grasp
NAD_binding_11
NAD_binding_2
NAD_binding_3 DUF108
Homoserine_dh
NAD_binding_3
NAD_binding_5 Inos-1-P_synth
NAD_binding_5
NAD_binding_7 NAD_binding_7
Sirohm_synth_C
Sirohm_synth_M
NAD_binding_8 Amino_oxidase
GLF
NAD_binding_8
NAD_Gly3P_dh_C NAD_Gly3P_dh_N
NAD_Gly3P_dh_N NAD_Gly3P_dh_C
NAD_Gly3P_dh_N
Octopine_DH
NAS NAS
NmrA GATA
NmrA
NNMT_PNMT_TEMT NNMT_PNMT_TEMT
NodS NodS
Nol1_Nop2_Fmu Nol1_Nop2_Fmu
Nol1_Nop2_Fmu_2
Nol1_Nop2_Fmu_2 Nol1_Nop2_Fmu
Nop Fibrillarin
NSP13 NSP10
NusB Nol1_Nop2_Fmu
OCD_Mu_crystall OCD_Mu_crystall
Oxidored_FMN NAD_binding_8
Pyr_redox_2
P5CR_dimer F420_oxidored
PARP_regulatory PARP_regulatory
Pox_polyA_pol
Pox_polyA_pol_C
Pox_polyA_pol_N
PCMT PCMT
PDH PDH
Phe_hydrox_dim FAD_binding_3
PNTB AlaDh_PNT_C
Polysacc_synt_2 Polysacc_synt_2
Pox_MCEL Pox_MCEL
Pox_mRNA-cap
PPTA GDI
PrmA PrmA
Ribosomal_L11
Ribosomal_L11_N
PRMT5 PRMT5
WD40
PS-DH ADH_zinc_N
KR
PUA Methyltrans_SAM
Put_DNA-bind_N CoA_binding
Pyr_redox AIF_C
E3_binding
FAD_binding_3
Pyr_redox
Pyr_redox_2
Pyr_redox_dim
Reductase_C
Rhodanese
Thioredoxin
Pyr_redox_2 AIF_C
DAO
E3_binding
ETF
FCSD-flav_bind
Fer2
Oxidored_FMN
Pyr_redox
Pyr_redox_2
Pyr_redox_dim
Reductase_C
Rhodanese
Rieske
Thioredoxin
Pyr_redox_3 Pyr_redox_3
Pyr_redox_dim Pyr_redox
Pyr_redox_2
Rad60-SLD ThiF
Rhodanese Pyr_redox_2
Ribosomal_L11 PrmA
Ribosomal_L7Ae Fibrillarin
RmlD_sub_bind RmlD_sub_bind
Rossmann-like DUF2520
rRNA_methylase rRNA_methylase
RrnaAD RrnaAD
S4 FtsJ
Sacchrp_dh_NADP Sacchrp_dh_NADP
SAM_MT SAM_MT
Semialdhyde_dh AcetDehyd-dimer
HMGL-like
Semialdhyde_dh
Semialdhyde_dhC
Semialdhyde_dhC Semialdhyde_dh
Shikimate_DH Shikimate_DH
Shikimate_dh_N
Shikimate_dh_N Shikimate_DH
Sirohm_synth_C NAD_binding_7
Sirohm_synth_M NAD_binding_7
Spermine_synth Spermine_synth
Succ_DH_flav_C FAD_binding_2
SWIRM Amino_oxidase
TehB TehB
THF_DHG_CYH THF_DHG_CYH_C
THF_DHG_CYH_C THF_DHG_CYH
THF_DHG_CYH_C
Thi4 Thi4
ThiF Atg8
Autophagy_act_C
E1_UFD
E2_bind
Rad60-SLD
ThiF
ThiS
UAE_UbL
UBA_e1_thiolCys
ubiquitin
UQ_con
Thioredoxin_3 Pyr_redox_2
THUMP UPF0020
TP_methylase NAD_binding_7
TPMT TPMT
TRAM tRNA_U5-meth_tr
TrkA_C TrkA_N
TrkA_N BK_channel_a
TrkA_C
TrkA_N
TRM TRM
Trm112p MTS
TrmK TrmK
tRNA_U5-meth_tr tRNA_U5-meth_tr
Trp_halogenase Trp_halogenase
TylF TylF
Ubie_methyltran Ubie_methyltran
UDPG_MGDP_dh UDPG_MGDP_dh_N
UDPG_MGDP_dh_C UDPG_MGDP_dh_N
UDPG_MGDP_dh_N UDPG_MGDP_dh
UDPG_MGDP_dh_C
UDPG_MGDP_dh_N
UPF0020 Methyltrans_SAM
UPF0020
WD40 Methyltransf_4
XdhC_C XdhC_C
XdhC_CoxI
XdhC_CoxI XdhC_C
YjeF_N Carb_kinase
FDF
YjeF_N
zf-CXXC DNA_methylase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...