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4  structures 1278  species 0  interactions 4746  sequences 77  architectures

Clan: NPR (CL0435)


Nitrogen permease regulator family Add an annotation

The several protein families of nitrogen permease regulators, that complex together and regulator TORC1 in response to amino acid starvation are likely to have arisen by a gene duplication event.

This clan contains 2 families and the total number of domains in the clan is 4746. The clan was built by P Coggill.

Literature references

  1. Neklesa TK, Davis RW;, PLoS Genet. 2009;5:e1000515.: A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. PUBMED:19521502 EPMC:19521502


This clan contains the following 2 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NPR2 (PF06218) 2582 (54.4%) View
NPR3 (PF03666) 2164 (45.6%) View
Total: 2 Total: 4746 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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