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753  structures 17950  species 30  interactions 112464  sequences 469  architectures

Clan: NTF2 (CL0051)


NTF2-like superfamily Add an annotation

This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.

This clan contains 27 families and the total number of domains in the clan is 112464. The clan was built by A Bateman.

Literature references

  1. Nagata Y, Mori K, Takagi M, Murzin AG, Damborsky J; , Proteins 2001;45:471-477.: Identification of protein fold and catalytic residues of gamma-hexachlorocyclohexane dehydrochlorinase LinA. PUBMED:11746694 EPMC:11746694


This clan contains the following 27 member families:

CaMKII_AD DUF1348 DUF2358 DUF3225 DUF3804 DUF3828 DUF3887 DUF4440 DUF4467 DUF4864 DUF4878 LEH Lumazine_bd_2 MBA1 MecA_N Mtr2 NTF2 PHZA_PHZB Ring_hydroxyl_B Scytalone_dh SnoaL SnoaL_2 SnoaL_3 SnoaL_4 Tim44 VirB8 WI12

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SnoaL_2 (PF12680) 29903 (26.6%) View
SnoaL_4 (PF13577) 10860 (9.7%) View
DUF4467 (PF14729) 9540 (8.5%) View
DUF3828 (PF12883) 7974 (7.1%) View
MecA_N (PF05223) 7673 (6.8%) View
Ring_hydroxyl_B (PF00866) 6333 (5.6%) View
NTF2 (PF02136) 6166 (5.5%) View
DUF4440 (PF14534) 6000 (5.3%) View
Tim44 (PF04280) 4779 (4.2%) View
VirB8 (PF04335) 4088 (3.6%) View
SnoaL (PF07366) 4075 (3.6%) View
SnoaL_3 (PF13474) 3375 (3.0%) View
LEH (PF07858) 2033 (1.8%) View
DUF1348 (PF07080) 1903 (1.7%) View
Pfam family Num. domains Alignment
CaMKII_AD (PF08332) 1372 (1.2%) View
DUF4878 (PF12870) 1301 (1.2%) View
DUF3887 (PF13026) 893 (0.8%) View
DUF2358 (PF10184) 889 (0.8%) View
PHZA_PHZB (PF03284) 836 (0.7%) View
DUF3225 (PF11533) 811 (0.7%) View
Lumazine_bd_2 (PF12893) 739 (0.7%) View
DUF4864 (PF16156) 293 (0.3%) View
Scytalone_dh (PF02982) 252 (0.2%) View
WI12 (PF07107) 145 (0.1%) View
MBA1 (PF07961) 126 (0.1%) View
Mtr2 (PF10429) 83 (0.1%) View
DUF3804 (PF12707) 22 (0.0%) View
Total: 27 Total: 112464 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 30 interactions for this clan. More...

Interacting families
Carot_N NTF2
DUF1348 DUF1348
DUF3225 DUF3225
DUF3828 DUF3828
DUF4440 DUF4440
DUF4467 DUF4467
DUF4878 DUF4878
Lumazine_bd_2 Lumazine_bd_2
MecA_N MecA_N
NTF2 Carot_N
PBP_dimer MecA_N
Pkinase CaMKII_AD
Rieske Ring_hydroxyl_B
Ring_hydroxyl_A Ring_hydroxyl_B
Ring_hydroxyl_B Rieske
Scytalone_dh Scytalone_dh
SnoaL SnoaL
SnoaL_2 SnoaL_2
SnoaL_3 SnoaL_3
SnoaL_4 SnoaL_4
Tim44 Tim44
VirB8 VirB8


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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