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935  structures 4276  species 32  interactions 36855  sequences 568  architectures

Clan: NTF2 (CL0051)

Summary

NTF2-like superfamily Add an annotation

This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.

This clan contains 38 families and the total number of domains in the clan is 36855. The clan was built by A Bateman.

Literature references

  1. Nagata Y, Mori K, Takagi M, Murzin AG, Damborsky J; , Proteins 2001;45:471-477.: Identification of protein fold and catalytic residues of gamma-hexachlorocyclohexane dehydrochlorinase LinA. PUBMED:11746694 EPMC:11746694

Members

This clan contains the following 38 member families:

CaMKII_AD DUF1348 DUF2358 DUF3225 DUF3804 DUF3828 DUF3887 DUF4348 DUF4440 DUF4467 DUF4518 DUF4783 DUF4829 DUF4864 DUF4878 DUF4904 DUF5104 DUF5105 Endopep_inhib LEH Lumazine_bd_2 MBA1 MecA_N MlaC Mtr2 NTF2 PHZA_PHZB Ring_hydroxyl_B Scytalone_dh SnoaL SnoaL_2 SnoaL_3 SnoaL_4 T4BSS_DotI_IcmL Tim44 TpcC VirB8 WI12

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SnoaL_2 (PF12680) 8806 (23.9%) View
SnoaL_4 (PF13577) 3795 (10.3%) View
NTF2 (PF02136) 3446 (9.4%) View
DUF4440 (PF14534) 2951 (8.0%) View
Tim44 (PF04280) 2470 (6.7%) View
SnoaL (PF07366) 2335 (6.3%) View
SnoaL_3 (PF13474) 1935 (5.3%) View
MlaC (PF05494) 1401 (3.8%) View
VirB8 (PF04335) 1088 (3.0%) View
DUF1348 (PF07080) 1021 (2.8%) View
Ring_hydroxyl_B (PF00866) 993 (2.7%) View
CaMKII_AD (PF08332) 941 (2.6%) View
DUF2358 (PF10184) 925 (2.5%) View
MecA_N (PF05223) 743 (2.0%) View
Lumazine_bd_2 (PF12893) 609 (1.7%) View
DUF3887 (PF13026) 325 (0.9%) View
Scytalone_dh (PF02982) 292 (0.8%) View
DUF4864 (PF16156) 261 (0.7%) View
DUF3225 (PF11533) 260 (0.7%) View
TpcC (PF12642) 250 (0.7%) View
continued
Pfam family Num. domains Alignment
DUF3828 (PF12883) 229 (0.6%) View
LEH (PF07858) 229 (0.6%) View
DUF4878 (PF12870) 216 (0.6%) View
WI12 (PF07107) 192 (0.5%) View
T4BSS_DotI_IcmL (PF11393) 166 (0.5%) View
DUF4783 (PF16022) 160 (0.4%) View
MBA1 (PF07961) 150 (0.4%) View
DUF4518 (PF15008) 138 (0.4%) View
DUF4348 (PF14254) 113 (0.3%) View
DUF5105 (PF17118) 84 (0.2%) View
Mtr2 (PF10429) 67 (0.2%) View
DUF5104 (PF17117) 62 (0.2%) View
Endopep_inhib (PF16800) 61 (0.2%) View
DUF4829 (PF16111) 61 (0.2%) View
PHZA_PHZB (PF03284) 49 (0.1%) View
DUF4467 (PF14729) 17 (0.0%) View
DUF3804 (PF12707) 11 (0.0%) View
DUF4904 (PF16247) 3 (0.0%) View
Total: 38 Total: 36855 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Interactions

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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